Peptide Database
265 therapeutic peptides with research summaries, clinical findings, and regulatory status.
Afamelanotide (Scenesse)
A synthetic 13-amino acid analog of alpha-melanocyte-stimulating hormone (alpha-MSH) with a substitution of norleucine at position 4 that confers enhanced potency and enzymatic stability. Afamelanotide activates melanocortin-1 receptors (MC1R) on melanocytes, stimulating eumelanin production independent of UV exposure. The resulting increase in skin eumelanin provides photoprotection by absorbing UV radiation and scavenging reactive oxygen species.
Argireline (Acetyl Hexapeptide-8)
Argireline is a synthetic six amino acid peptide (Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2) designed to attenuate neurotransmitter release at the neuromuscular junction. It functions as a competitive inhibitor of the SNARE complex, reducing catecholamine release and potentially diminishing muscle contraction intensity in facial expression muscles. This mechanism provides a topical alternative rationale to botulinum toxin for addressing expression lines, though with markedly lower potency.
Matrixyl (Palmitoyl Pentapeptide-4)
Matrixyl is a lipopeptide composed of a pentapeptide sequence (Lys-Thr-Thr-Lys-Ser) attached to a palmitic acid moiety to enhance dermal penetration. It is proposed to stimulate fibroblast activity and upregulate synthesis of extracellular matrix components including collagen types I and III, fibronectin, and hyaluronic acid. The peptide serves as a matrikine fragment mimetic, signaling tissue remodeling pathways in aged or photodamaged skin.
Matrixyl 3000
Matrixyl 3000 is a proprietary combination of two lipopeptides: palmitoyl tripeptide-1 (Pal-GHK) and palmitoyl tetrapeptide-7 (Pal-GQPR). The formulation is designed to synergistically promote collagen and fibronectin synthesis while reducing interleukin-6 mediated inflammation in dermal fibroblasts. Both peptides carry palmitic acid for enhanced lipid solubility and stratum corneum permeation.
Matrixyl Synthe'6 (Palmitoyl Tripeptide-38)
Palmitoyl tripeptide-38 is a synthetic lipopeptide designed to stimulate synthesis of six major constituents of the dermal matrix: collagen I, III, and IV, fibronectin, hyaluronic acid, and laminin 5. It is proposed to activate transforming growth factor beta (TGF-beta) signaling in fibroblasts, thereby promoting coordinated extracellular matrix assembly. The palmitic acid conjugate enhances dermal bioavailability when applied topically.
SYN-AKE (Dipeptide Diaminobutyroyl Benzylamide Diacetate)
SYN-AKE is a synthetic dipeptide derivative inspired by the venom peptide waglerin-1 from the Temple viper. It acts as a competitive antagonist at nicotinic acetylcholine receptors on the postsynaptic muscle membrane, thereby reducing muscle contraction and potentially smoothing expression lines. The compound is marketed as a topical alternative to botulinum toxin, though with substantially lower receptor affinity and clinical effect.
SNAP-8 (Acetyl Octapeptide-3)
SNAP-8 is an elongated derivative of Argireline, consisting of eight amino acids (Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2) designed to further inhibit SNARE complex formation and catecholamine-mediated neurotransmitter release. By extending the peptide sequence, the molecule is hypothesized to achieve enhanced binding and greater reduction in muscle contraction intensity in facial expression zones. Like its hexapeptide predecessor, it is positioned as a non-invasive topical anti-wrinkle agent.
Leuphasyl (Pentapeptide-18)
Leuphasyl is a synthetic pentapeptide (Tyr-D-Ala-Gly-Phe-Leu) that mimics the N-terminal sequence of enkephalin and modulates acetylcholine receptor activity at the neuromuscular junction. It is proposed to stabilize the receptor in an inactive conformation, reducing the frequency of muscle fiber contraction without blocking neurotransmission. This mechanism is intended to yield a topical wrinkle-smoothing effect with cosmetic applications.
Vialox (Pentapeptide-3)
Vialox is a synthetic pentapeptide designed to modulate neuromuscular signaling by interfering with acetylcholine receptor activation. The exact sequence is proprietary, but the peptide is marketed as a topical agent to reduce muscle contraction intensity in areas prone to dynamic wrinkles. It is positioned alongside other neuromodulating peptides as a non-invasive alternative to botulinum toxin.
Rigin (Palmitoyl Tetrapeptide-7)
Rigin is a lipopeptide composed of the tetrapeptide sequence Gly-Gln-Pro-Arg conjugated to palmitic acid. It is designed to reduce production of interleukin-6 and other pro-inflammatory cytokines in dermal fibroblasts, thereby mitigating chronic low-grade inflammation associated with skin aging. By modulating the inflammatory microenvironment, the peptide is proposed to support matrix integrity and reduce glycation-induced damage.
Biopeptide CL (Palmitoyl Tripeptide-5)
Palmitoyl Tripeptide-5 is a synthetic lipopeptide consisting of a tripeptide sequence conjugated to palmitic acid to enhance dermal penetration. The peptide is designed to stimulate collagen synthesis by mimicking the activity of thrombospondin-1, a matricellular protein involved in extracellular matrix remodeling. Its therapeutic rationale centers on attenuating photoaging and improving skin elasticity through upregulation of Types I and III collagen in dermal fibroblasts.
Decorinyl (Tripeptide-10 Citrulline)
Decorinyl is a modified tripeptide featuring citrulline substitution, engineered to interact with decorin, a small leucine-rich proteoglycan that regulates collagen fibrillogenesis. The peptide is proposed to enhance decorin production and activity in the dermis, thereby promoting organized collagen assembly and tensile strength. Its development targets improvement of dermal structural integrity in aging and photoaged skin.
Haloxyl (Chrysin + Palmitoyl Peptides)
Haloxyl is a combination ingredient consisting of chrysin, a naturally occurring flavone, and palmitoyl oligopeptides designed to address periorbital hyperpigmentation and edema. The chrysin component is thought to activate enzyme systems involved in bilirubin and hemoglobin clearance, while the palmitoyl peptides enhance dermal penetration and stimulate lymphatic drainage. This dual-mechanism approach targets the appearance of dark circles attributable to both vascular congestion and iron deposition.
Eyeseryl (Acetyl Tetrapeptide-5)
Acetyl Tetrapeptide-5 is a synthetic tetrapeptide modified with an acetyl group to improve stability and cellular uptake. The peptide is proposed to reduce periorbital edema by modulating capillary permeability and enhancing lymphatic drainage, potentially through downregulation of pro-inflammatory cytokines such as interleukin-1. Its application is focused on reduction of under-eye puffiness and fluid accumulation.
Trylagen (Tripeptide-10 Complex)
Trylagen is a proprietary complex incorporating Tripeptide-10 Citrulline along with additional bioactive peptides formulated to support collagen and elastin network architecture. The complex aims to influence multiple stages of extracellular matrix synthesis and assembly, including fibroblast proliferation, procollagen processing, and elastin fiber organization. The therapeutic rationale is directed toward comprehensive photoaging correction and improvement of skin firmness.
Myristoyl Pentapeptide-17
Myristoyl Pentapeptide-17 is a lipopeptide composed of a pentapeptide sequence conjugated to myristic acid to facilitate penetration of the hair follicle and dermal layers. It is marketed primarily for enhancement of eyelash and eyebrow growth through proposed stimulation of keratin gene expression and prolongation of the anagen phase of the hair cycle. The peptide is intended for cosmetic applications related to hair conditioning and growth.
Palmitoyl Tripeptide-1
Palmitoyl Tripeptide-1 is a synthetic lipopeptide comprising a tripeptide linked to palmitic acid, designed to mimic a portion of the Type I collagen molecule. By binding to fibroblast receptors, it is hypothesized to trigger signaling cascades that upregulate collagen and glycosaminoglycan synthesis. This peptide is widely incorporated into topical anti-aging formulations to promote dermal matrix regeneration and reduce the appearance of fine lines.
Copper Peptide (Prezatide Copper Acetate)
Prezatide Copper Acetate is a tripeptide-copper complex, most commonly represented by the sequence Gly-His-Lys bound to a copper ion. Copper peptides are proposed to enhance wound healing, collagen synthesis, and angiogenesis through modulation of matrix metalloproteinases and growth factor activity. The copper moiety is thought to play a critical role in stabilizing the peptide and serving as a cofactor for lysyl oxidase, an enzyme essential for collagen and elastin cross-linking.
Melitane (Acetyl Hexapeptide-1)
Acetyl Hexapeptide-1 is a synthetic hexapeptide designed to stimulate melanin synthesis by acting as an agonist at melanocortin-1 receptors on melanocytes. The acetyl modification is intended to improve peptide stability and cellular permeability. Its therapeutic rationale is to promote tanning and photoprotection through increased melanogenesis, potentially offering a biomimetic alternative to UV exposure for pigmentation enhancement.