Evidence-Based Research

Peptide Research Database

265Peptides Cataloged
90FDA Approved
41In Clinical Trials
134Research / Investigational

Showing 265 of 265 peptides

BPC-157

Recovery
Research Phase

A synthetic gastric pentadecapeptide derived from a protein found in human gastric juice. BPC-157 promotes angiogenesis and the expression of growth f...

Subcutaneous injection, Oral

TB-500 (Thymosin Beta-4)

Recovery
In Clinical Trials

Thymosin Beta-4 is a 43-amino acid actin-sequestering protein involved in cell migration, differentiation, and tissue repair. It promotes wound healin...

Subcutaneous injection

GHK-Cu

Recovery
Research Phase

A naturally occurring copper-binding tripeptide (glycyl-L-histidyl-L-lysine) found in human plasma, saliva, and urine. GHK-Cu activates tissue remodel...

Topical, Subcutaneous injection

DSIP (Delta Sleep-Inducing Peptide)

Recovery
Research Phase

A naturally occurring nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) originally isolated from cerebral venous blood of rabbits during induced sleep...

Subcutaneous injection, Intravenous, Intranasal

Pentosan Polysulfate (Elmiron)

Recovery
FDA Approved

A semi-synthetic sulfated polysaccharide derived from beechwood hemicellulose with structural similarities to glycosaminoglycans. Pentosan polysulfate...

Oral

Semaglutide (Ozempic/Wegovy)

Metabolic
FDA Approved

A glucagon-like peptide-1 receptor agonist (GLP-1 RA) with 94% amino acid homology to native GLP-1. Semaglutide enhances glucose-dependent insulin sec...

Subcutaneous injection (weekly), Oral (daily - Rybelsus)

Tirzepatide (Mounjaro/Zepbound)

Metabolic
FDA Approved

A first-in-class dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonist. Tirzepatide activates both incretin pathways simu...

Subcutaneous injection (weekly)

Retatrutide

Metabolic
In Clinical Trials

An investigational triple hormone receptor agonist targeting GLP-1, GIP, and glucagon receptors simultaneously. The glucagon receptor component adds t...

Subcutaneous injection (weekly)

AOD-9604

Metabolic
Investigational

A modified 16-amino acid fragment (amino acids 176-191) of the C-terminus of human growth hormone with an added tyrosine at the N-terminus. AOD-9604 r...

Subcutaneous injection, Oral

Liraglutide (Saxenda/Victoza)

Metabolic
FDA Approved

A GLP-1 receptor agonist with 97% homology to native GLP-1, modified with a fatty acid side chain (C-16 palmitoyl) enabling albumin binding and a half...

Subcutaneous injection (daily)

Exenatide (Byetta/Bydureon)

Metabolic
FDA Approved

A synthetic version of exendin-4, a 39-amino acid peptide originally isolated from the saliva of the Gila monster lizard (Heloderma suspectum). Exenat...

Subcutaneous injection (twice daily or weekly extended-release)

Glucagon

Metabolic
FDA Approved

A 29-amino acid peptide hormone produced by alpha cells of the pancreatic islets of Langerhans. Glucagon acts primarily on hepatocytes via the glucago...

Subcutaneous injection, Intramuscular injection, Intranasal

Pramlintide (Symlin)

Metabolic
FDA Approved

A synthetic analog of amylin (islet amyloid polypeptide), a 37-amino acid peptide hormone co-secreted with insulin from pancreatic beta cells. Pramlin...

Subcutaneous injection (before meals)

Dulaglutide (Trulicity)

Metabolic
FDA Approved

A long-acting GLP-1 receptor agonist consisting of a GLP-1 analog covalently linked to a modified human IgG4 Fc fragment via a peptide linker. This fu...

Subcutaneous injection (weekly)

Lixisenatide (Adlyxin)

Metabolic
FDA Approved

A selective GLP-1 receptor agonist derived from exendin-4 with a modified C-terminal tail containing six lysine residues. Lixisenatide has a half-life...

Subcutaneous injection (daily)

Setmelanotide (Imcivree)

Metabolic
FDA Approved

A cyclic peptide melanocortin-4 receptor (MC4R) agonist designed to restore MC4R signaling in patients with obesity caused by genetic deficiencies in ...

Subcutaneous injection (daily)

CJC-1295

Hormone
In Clinical Trials

A synthetic analog of growth hormone-releasing hormone (GHRH) with a Drug Affinity Complex (DAC) that binds to albumin, extending its half-life from m...

Subcutaneous injection

Ipamorelin

Hormone
In Clinical Trials

A highly selective growth hormone secretagogue that acts on ghrelin/GHS receptors in the pituitary gland to stimulate GH release. Unlike other GH secr...

Subcutaneous injection

Sermorelin

Hormone
FDA Approved

A synthetic 29-amino acid analog of GHRH representing the shortest fully functional fragment of the native 44-amino acid hormone. Sermorelin stimulate...

Subcutaneous injection

Tesamorelin (Egrifta)

Hormone
FDA Approved

A synthetic GHRH analog consisting of the 44-amino acid sequence of human GHRH with a trans-3-hexenoic acid modification at the N-terminus to improve ...

Subcutaneous injection (daily)

PT-141 (Bremelanotide / Vyleesi)

Hormone
FDA Approved

A synthetic cyclic heptapeptide melanocortin receptor agonist that activates MC3R and MC4R in the central nervous system. Unlike PDE5 inhibitors that ...

Subcutaneous injection (as needed)

Kisspeptin

Hormone
In Clinical Trials

A neuropeptide encoded by the KISS1 gene that serves as the master upstream regulator of the hypothalamic-pituitary-gonadal (HPG) axis. Kisspeptin act...

Intravenous, Subcutaneous injection

Oxytocin

Hormone
FDA Approved

A nine-amino acid cyclic neuropeptide produced in the hypothalamus and released from the posterior pituitary. Oxytocin mediates uterine contractions d...

Intravenous, Intramuscular injection, Intranasal

GHRP-2

Hormone
Investigational

A synthetic hexapeptide growth hormone secretagogue that acts on the ghrelin receptor (GHS-R1a) in the hypothalamus and pituitary to stimulate growth ...

Subcutaneous injection, Intravenous

GHRP-6

Hormone
Investigational

A synthetic hexapeptide growth hormone secretagogue that stimulates the anterior pituitary via GHS-R1a receptor activation. GHRP-6 produces significan...

Subcutaneous injection, Intravenous

Hexarelin

Hormone
Investigational

A synthetic hexapeptide growth hormone secretagogue with the highest GH-releasing potency among GHRPs. Hexarelin binds both GHS-R1a and CD36 (scavenge...

Subcutaneous injection, Intravenous

MK-677 (Ibutamoren)

Hormone
In Clinical Trials

An orally bioavailable, non-peptide growth hormone secretagogue that mimics the action of ghrelin at the GHS-R1a receptor. MK-677 stimulates sustained...

Oral

Macimorelin (Macrilen)

Hormone
FDA Approved

An orally bioavailable growth hormone secretagogue approved as a diagnostic agent for adult growth hormone deficiency (AGHD). Macimorelin stimulates G...

Oral

Cosyntropin (Cortrosyn)

Hormone
FDA Approved

A synthetic peptide consisting of the first 24 amino acids of the 39-amino acid adrenocorticotropic hormone (ACTH). Cosyntropin retains full biologica...

Intravenous, Intramuscular injection

Gonadorelin (GnRH)

Hormone
FDA Approved

A synthetic decapeptide identical to endogenous gonadotropin-releasing hormone. Gonadorelin stimulates the release of luteinizing hormone (LH) and fol...

Intravenous, Subcutaneous injection

Leuprolide (Lupron)

Reproductive
FDA Approved

A synthetic nonapeptide GnRH agonist approximately 15-fold more potent than native GnRH. After an initial stimulatory phase (flare effect) lasting 1-2...

Subcutaneous injection, Intramuscular injection (depot)

Goserelin (Zoladex)

Reproductive
FDA Approved

A synthetic decapeptide GnRH agonist administered as a biodegradable subcutaneous implant that provides sustained drug release over 1 or 3 months. Lik...

Subcutaneous implant

Cetrorelix (Cetrotide)

Reproductive
FDA Approved

A synthetic decapeptide GnRH antagonist that competitively blocks pituitary GnRH receptors, producing immediate and dose-dependent suppression of LH a...

Subcutaneous injection

Ganirelix

Reproductive
FDA Approved

A synthetic decapeptide GnRH antagonist that competitively and reversibly blocks GnRH receptors on pituitary gonadotroph cells. Ganirelix rapidly supp...

Subcutaneous injection

Carbetocin

Reproductive
In Clinical Trials

A long-acting synthetic analog of oxytocin with a modified disulfide bridge that confers resistance to enzymatic degradation. Carbetocin has a half-li...

Intravenous, Intramuscular injection

Atosiban

Reproductive
Investigational

A competitive oxytocin/vasopressin V1a receptor antagonist used as a tocolytic agent to delay preterm labor. Atosiban blocks oxytocin-mediated myometr...

Intravenous

Semax

Cognitive
FDA Approved

A synthetic heptapeptide analog of the ACTH(4-7) fragment (Met-Glu-His-Phe-Pro-Gly-Pro) with nootropic and neuroprotective properties. Semax modulates...

Intranasal

Selank

Cognitive
Investigational

A synthetic analog of the endogenous tetrapeptide tuftsin (Thr-Lys-Pro-Arg) with an added Pro-Gly-Pro sequence for stability. Selank exhibits anxiolyt...

Intranasal

Cerebrolysin

Cognitive
Investigational

A porcine brain-derived peptide preparation consisting of low-molecular-weight neuropeptides and free amino acids that mimic the action of endogenous ...

Intravenous, Intramuscular injection

P21 (Peptide)

Cognitive
Research Phase

A small synthetic peptide derived from the active region of ciliary neurotrophic factor (CNTF) designed to promote neurogenesis and synaptic plasticit...

Subcutaneous injection, Intranasal

Epithalon (Epitalon)

Longevity
Research Phase

A synthetic tetrapeptide (Ala-Glu-Asp-Gly) based on the natural epithalamin peptide produced by the pineal gland. Epithalon activates telomerase, the ...

Subcutaneous injection, Intravenous

MOTS-c

Longevity
Research Phase

A mitochondrial-derived peptide encoded by the 12S rRNA gene of mitochondrial DNA. MOTS-c is a 16-amino acid peptide that acts as an exercise mimetic ...

Subcutaneous injection

Humanin

Longevity
Research Phase

A 24-amino acid mitochondrial-derived peptide encoded within the 16S rRNA region of mitochondrial DNA. Humanin exerts cytoprotective and neuroprotecti...

Subcutaneous injection, Intravenous

NAD+ Precursors (NMN)

Longevity
In Clinical Trials

Nicotinamide mononucleotide (NMN) is a direct biosynthetic precursor to nicotinamide adenine dinucleotide (NAD+), a coenzyme essential for cellular me...

Oral, Intravenous, Sublingual

SS-31 (Elamipretide)

Longevity
In Clinical Trials

A mitochondria-targeted tetrapeptide (D-Arg-dimethylTyr-Lys-Phe-NH2) that selectively concentrates in the inner mitochondrial membrane by binding to c...

Subcutaneous injection, Intravenous

FOXO4-DRI

Longevity
Research Phase

A D-retro-inverso peptide designed to disrupt the interaction between FOXO4 and p53 in senescent cells. In senescent cells, FOXO4 sequesters p53 away ...

Subcutaneous injection, Intravenous

Thymalin

Immune
Investigational

A peptide bioregulator originally extracted from bovine thymus gland, consisting of a mixture of polypeptides that modulate immune function. Thymalin ...

Intramuscular injection

LL-37

Immune
Research Phase

The only human cathelicidin antimicrobial peptide, a 37-amino acid cationic peptide cleaved from the precursor protein hCAP18. LL-37 disrupts microbia...

Subcutaneous injection, Topical

VIP (Vasoactive Intestinal Peptide)

Immune
Investigational

A 28-amino acid neuropeptide widely distributed in the central and peripheral nervous systems and immune cells. VIP acts through VPAC1 and VPAC2 recep...

Intranasal, Intravenous, Subcutaneous injection

Thymosin Alpha 1 (Zadaxin)

Immune
Investigational

A 28-amino acid peptide originally isolated from thymic tissue (thymosin fraction 5) that serves as a potent immunomodulator. Thymosin alpha 1 enhance...

Subcutaneous injection

Thymopentin (TP-5)

Immune
Investigational

A synthetic pentapeptide (Arg-Lys-Asp-Val-Tyr) corresponding to residues 32-36 of thymopoietin, a thymic hormone involved in T-cell differentiation. T...

Subcutaneous injection, Intramuscular injection

Thymulin

Immune
Research Phase

A zinc-containing nonapeptide (facteur thymique serique) produced exclusively by thymic epithelial cells. Thymulin requires zinc for biological activi...

Subcutaneous injection, Intranasal

KPV

Immune
Research Phase

A C-terminal tripeptide fragment (Lys-Pro-Val) of alpha-melanocyte-stimulating hormone (alpha-MSH) that retains potent anti-inflammatory activity with...

Oral, Topical, Subcutaneous injection

Enfuvirtide (Fuzeon)

Antimicrobial
FDA Approved

A 36-amino acid synthetic peptide that inhibits HIV-1 entry into CD4+ T-cells by blocking the gp41-mediated membrane fusion step. Enfuvirtide binds to...

Subcutaneous injection (twice daily)

Melanotan II

Performance
Research Phase

A synthetic cyclic analog of alpha-melanocyte stimulating hormone (alpha-MSH) that non-selectively activates melanocortin receptors MC1R through MC5R....

Subcutaneous injection

Teriparatide (Forteo)

Bone
FDA Approved

A recombinant form of the first 34 amino acids of human parathyroid hormone (PTH 1-34). When administered intermittently via daily subcutaneous inject...

Subcutaneous injection (daily)

Abaloparatide (Tymlos)

Bone
FDA Approved

A synthetic 34-amino acid peptide analog of parathyroid hormone-related protein (PTHrP 1-34) that selectively activates the RG conformation of the PTH...

Subcutaneous injection (daily)

Calcitonin

Bone
FDA Approved

A 32-amino acid peptide hormone naturally produced by parafollicular C-cells of the thyroid gland. Calcitonin inhibits osteoclast-mediated bone resorp...

Intranasal, Subcutaneous injection, Intramuscular injection

Vosoritide (Voxzogo)

Bone
FDA Approved

A C-type natriuretic peptide (CNP) analog that acts as an agonist at the natriuretic peptide receptor B (NPR-B) on growth plate chondrocytes. Vosoriti...

Subcutaneous injection (daily)

Vasopressin (ADH)

Renal
FDA Approved

A nine-amino acid cyclic peptide hormone (arginine vasopressin) produced in the hypothalamus and released from the posterior pituitary. Vasopressin ac...

Intravenous, Intramuscular injection, Subcutaneous injection

Desmopressin (DDAVP)

Renal
FDA Approved

A synthetic analog of vasopressin with enhanced V2 receptor selectivity and minimal V1a vasopressor activity. Desmopressin has a deaminated cysteine a...

Intranasal, Oral, Subcutaneous injection, Intravenous

Terlipressin

Renal
FDA Approved

A synthetic vasopressin analog and prodrug that is cleaved by endopeptidases to release lysine-vasopressin. Terlipressin has greater V1a receptor sele...

Intravenous

Eptifibatide (Integrilin)

Cardiovascular
FDA Approved

A synthetic cyclic heptapeptide modeled after the KGD (Lys-Gly-Asp) disintegrin sequence found in the venom of the southeastern pygmy rattlesnake (Sis...

Intravenous

Nesiritide (Natrecor)

Cardiovascular
FDA Approved

A recombinant form of human B-type natriuretic peptide (BNP), a 32-amino acid peptide naturally produced by ventricular cardiomyocytes in response to ...

Intravenous

Angiotensin II (Giapreza)

Cardiovascular
FDA Approved

A synthetic form of the endogenous octapeptide angiotensin II, the primary effector of the renin-angiotensin system. Angiotensin II acts on AT1 recept...

Intravenous

Bivalirudin (Angiomax)

Hematology
FDA Approved

A synthetic 20-amino acid peptide that acts as a direct thrombin inhibitor by binding both the catalytic active site and anion-binding exosite 1 of th...

Intravenous

Romiplostim (Nplate)

Hematology
FDA Approved

A thrombopoietin (TPO) receptor agonist consisting of a peptide sequence that binds the TPO receptor (c-Mpl) fused to an IgG1 Fc domain (peptibody). R...

Subcutaneous injection (weekly)

Pegcetacoplan (Empaveli)

Hematology
FDA Approved

A pegylated cyclic peptide that inhibits complement component C3, the central node of all three complement activation pathways (classical, lectin, and...

Subcutaneous infusion

Carfilzomib (Kyprolis)

Oncology
FDA Approved

A tetrapeptide epoxyketone proteasome inhibitor that irreversibly binds the chymotrypsin-like (beta5) subunit of the 20S proteasome. By blocking prote...

Intravenous

Bortezomib (Velcade)

Oncology
FDA Approved

A modified dipeptidyl boronic acid that reversibly inhibits the chymotrypsin-like activity of the 26S proteasome. Bortezomib disrupts the ubiquitin-pr...

Subcutaneous injection, Intravenous

Lutetium-177 dotatate (Lutathera)

Oncology
FDA Approved

A radiolabeled somatostatin analog consisting of the peptide DOTA-Tyr3-octreotate chelated to the beta-emitting radioisotope lutetium-177. Lutathera b...

Intravenous

Leuprolide (Lupron) - Oncology

Oncology
FDA Approved

A GnRH agonist used in oncology for androgen deprivation therapy (ADT) in prostate cancer and hormone suppression in premenopausal breast cancer. Chro...

Intramuscular injection (depot), Subcutaneous injection

Octreotide (Sandostatin)

Gastrointestinal
FDA Approved

A synthetic octapeptide analog of somatostatin with a substantially longer half-life (90 minutes IV, 6 hours subcutaneous vs. 2 minutes for native som...

Subcutaneous injection, Intramuscular injection (LAR), Intravenous

Lanreotide (Somatuline Depot)

Gastrointestinal
FDA Approved

A synthetic octapeptide analog of somatostatin with high affinity for SSTR2 and moderate affinity for SSTR5 receptors. Lanreotide is formulated as a s...

Deep subcutaneous injection (monthly)

Pasireotide (Signifor)

Gastrointestinal
FDA Approved

A multireceptor-targeted somatostatin analog with high binding affinity for SSTR1, SSTR2, SSTR3, and SSTR5, particularly notable for its 40-fold great...

Subcutaneous injection (twice daily), Intramuscular injection (monthly LAR)

Plecanatide (Trulance)

Gastrointestinal
FDA Approved

A synthetic 16-amino acid peptide structurally related to uroguanylin, an endogenous intestinal peptide that regulates fluid and electrolyte homeostas...

Oral

Linaclotide (Linzess)

Gastrointestinal
FDA Approved

A synthetic 14-amino acid peptide structurally related to the heat-stable enterotoxin of Escherichia coli and the endogenous peptide guanylin. Linaclo...

Oral

Secretin

Gastrointestinal
FDA Approved

A 27-amino acid peptide hormone produced by S-cells of the duodenal and jejunal mucosa in response to acidic chyme entering the small intestine. Secre...

Intravenous

Larazotide

Gastrointestinal
In Clinical Trials

A synthetic octapeptide derived from Vibrio cholerae zonula occludens toxin that acts as a tight junction regulator. Larazotide acetate modulates inte...

Oral

Ziconotide (Prialt)

Pain
FDA Approved

A synthetic 25-amino acid peptide identical to omega-conotoxin MVIIA, a neurotoxin found in the venom of the marine cone snail Conus magus. Ziconotide...

Intrathecal infusion

Difelikefalin (Korsuva)

Pain
FDA Approved

A selective kappa-opioid receptor (KOR) agonist peptide that does not cross the blood-brain barrier, providing peripheral analgesia and anti-pruritic ...

Intravenous (post-dialysis)

ARA-290

Pain
In Clinical Trials

A synthetic 11-amino acid peptide derived from the structure of erythropoietin (EPO) that selectively activates the innate repair receptor (IRR), a he...

Subcutaneous injection, Intravenous

Afamelanotide (Scenesse)

Dermatology
FDA Approved

A synthetic 13-amino acid analog of alpha-melanocyte-stimulating hormone (alpha-MSH) with a substitution of norleucine at position 4 that confers enha...

Subcutaneous implant

Pentagastrin

Diagnostic
FDA Approved

A synthetic pentapeptide containing the C-terminal tetrapeptide sequence of gastrin (Trp-Met-Asp-Phe-NH2) linked to beta-alanine. Pentagastrin stimula...

Subcutaneous injection, Intramuscular injection

Icatibant (Firazyr)

Immune
FDA Approved

A synthetic decapeptide bradykinin B2 receptor antagonist containing five non-natural amino acids for enhanced stability and receptor selectivity. Ica...

Subcutaneous injection

Palmitoylethanolamide (PEA)

Pain
Research Phase

An endogenous fatty acid amide belonging to the N-acylethanolamine family, naturally produced by cells in response to tissue damage and inflammation. ...

Oral

Orforglipron

Metabolic
In Clinical Trials

Orforglipron is a non-peptide, oral small-molecule glucagon-like peptide-1 receptor (GLP-1R) agonist designed to overcome the need for injectable deli...

Oral

Mazdutide

Metabolic
In Clinical Trials

Mazdutide is a dual glucagon-like peptide-1 (GLP-1) and glucagon receptor agonist delivered as a synthetic peptide. By co-activating both receptors, i...

Subcutaneous injection

Survodutide

Metabolic
In Clinical Trials

Survodutide is a dual agonist targeting both the glucagon-like peptide-1 (GLP-1) and glucagon receptors, formulated as a peptide for subcutaneous admi...

Subcutaneous injection

CagriSema

Metabolic
In Clinical Trials

CagriSema is a fixed-ratio combination of cagrilintide, an amylin analog, and semaglutide, a GLP-1 receptor agonist, both delivered as peptides via su...

Subcutaneous injection

Amycretin

Metabolic
In Clinical Trials

Amycretin is a dual agonist targeting both the amylin and calcitonin receptors, designed as a peptide therapeutic for obesity. Amylin receptor activat...

Subcutaneous injection

Efinopegdutide

Metabolic
In Clinical Trials

Efinopegdutide is a long-acting dual agonist of the GLP-1 and glucagon receptors, utilizing PEGylation to extend half-life and enable once-weekly dosi...

Subcutaneous injection

Danuglipron

Metabolic
In Clinical Trials

Danuglipron is an oral, non-peptide small-molecule agonist of the GLP-1 receptor developed to provide convenient daily dosing for type 2 diabetes and ...

Oral

Ecnoglutide

Metabolic
In Clinical Trials

Ecnoglutide is a long-acting GLP-1 receptor agonist peptide designed for once-weekly subcutaneous administration. It acts by enhancing glucose-depende...

Subcutaneous injection

Cotadutide

Metabolic
In Clinical Trials

Cotadutide is a dual agonist of the GLP-1 and glucagon receptors formulated as a peptide for subcutaneous injection. It is designed to harness GLP-1-m...

Subcutaneous injection

Glepaglutide

Metabolic
In Clinical Trials

Glepaglutide is a long-acting GLP-2 receptor agonist peptide developed for the treatment of short bowel syndrome. GLP-2 promotes intestinal growth, en...

Subcutaneous injection

Apraglutide

Metabolic
In Clinical Trials

Apraglutide is a long-acting glucagon-like peptide-2 (GLP-2) receptor agonist designed to promote intestinal growth and improve absorption in patients...

Subcutaneous injection

Teduglutide (Gattex)

Metabolic
FDA Approved

Teduglutide is a recombinant analogue of human glucagon-like peptide-2 (GLP-2) comprising 33 amino acids with a single amino acid substitution that co...

Subcutaneous injection

Beinaglutide

Metabolic
FDA Approved

Beinaglutide is a recombinant glucagon-like peptide-1 (GLP-1) receptor agonist engineered with structural modifications to prolong plasma half-life an...

Subcutaneous injection

Albiglutide (Tanzeum)

Metabolic
FDA Approved

Albiglutide is a GLP-1 receptor agonist consisting of a tandem repeat of modified human GLP-1 sequences fused to human albumin, creating a protein of ...

Subcutaneous injection

Taspoglutide

Metabolic
Investigational

Taspoglutide is a long-acting glucagon-like peptide-1 (GLP-1) receptor agonist derived from human GLP-1 with amino acid substitutions designed to resi...

Subcutaneous injection

Pemvidutide

Metabolic
In Clinical Trials

Pemvidutide is a dual receptor agonist targeting both glucagon-like peptide-1 (GLP-1) and glucagon receptors, designed to combine the insulinotropic a...

Subcutaneous injection

Cagrilintide

Metabolic
In Clinical Trials

Cagrilintide is a long-acting amylin analogue engineered with structural modifications to extend half-life and enable once-weekly dosing for the treat...

Subcutaneous injection

Enlicitide

Metabolic
Investigational

Enlicitide is an investigational peptide agonist designed to modulate metabolic pathways involved in energy balance and glucose homeostasis. Limited p...

Subcutaneous injection

Capromorelin (Entyce)

Hormone
FDA Approved

Capromorelin is a selective ghrelin receptor agonist, or growth hormone secretagogue, that mimics the endogenous peptide hormone ghrelin by binding to...

Oral

Anamorelin (Adlumiz)

Hormone
FDA Approved

Anamorelin is an orally active selective ghrelin receptor agonist designed to stimulate appetite and promote anabolic processes by mimicking endogenou...

Oral

Relamorelin

Hormone
Investigational

Relamorelin is a synthetic pentapeptide ghrelin receptor agonist designed to stimulate growth hormone secretion and promote gastric motility. It binds...

Subcutaneous injection

Mod GRF 1-29 (CJC-1295 no DAC)

Hormone
Research Phase

Modified GRF 1-29 is a synthetic analogue of growth hormone releasing hormone (GHRH) comprising 29 amino acids with four amino acid substitutions to e...

Subcutaneous injection

Tabimorelin

Hormone
Investigational

Tabimorelin is an orally active synthetic ghrelin mimetic and selective GHS-R1a agonist developed to stimulate growth hormone release. Unlike peptide ...

Oral

Somatropin (Genotropin)

Hormone
FDA Approved

Somatropin is recombinant human growth hormone (rhGH) consisting of 191 amino acids identical in sequence to endogenous pituitary growth hormone. It b...

Subcutaneous injection

Somapacitan (Sogroya)

Hormone
FDA Approved

Somapacitan is a long-acting growth hormone analogue engineered by attaching an albumin-binding moiety to recombinant human growth hormone. This modif...

Subcutaneous injection

Lonapegsomatropin (Skytrofa)

Hormone
FDA Approved

Lonapegsomatropin is a long-acting prodrug of somatropin created through site-specific PEGylation that releases active growth hormone after administra...

Subcutaneous injection

Pegvisomant (Somavert)

Hormone
FDA Approved

Pegvisomant is a PEGylated growth hormone receptor antagonist engineered from human growth hormone with nine amino acid substitutions that confer anta...

Subcutaneous injection

Mecasermin (Increlex)

Hormone
FDA Approved

Mecasermin is recombinant human insulin-like growth factor 1 (IGF-1) consisting of 70 amino acids identical to the endogenous peptide hormone. It bind...

Subcutaneous injection

GHRH (Sermorelin 1-44)

Hormone
Investigational

Sermorelin is a synthetic 44-amino acid peptide corresponding to the biologically active portion of human growth hormone releasing hormone (GHRH). It ...

Subcutaneous injection

Ghrelin (Native)

Hormone
Research Phase

Ghrelin is a naturally occurring 28-amino acid peptide hormone produced primarily in the stomach with an essential octanoyl modification at serine-3 r...

Intravenous

Obestatin

Hormone
Research Phase

Obestatin is a 23-amino acid peptide hormone derived from post-translational processing of the ghrelin gene product preproghrelin. It was initially pr...

Subcutaneous injection, Intravenous

GHRP-1

Hormone
Research Phase

Growth Hormone Releasing Peptide-1 is a synthetic hexapeptide belonging to the growth hormone secretagogue family. It acts as a weak agonist at the gh...

Subcutaneous injection, Intravenous

Pentadeca Arginate (PDA)

Recovery
Research Phase

Pentadeca Arginate is a synthetic 15-arginine polypeptide designed to enhance cellular uptake and delivery of therapeutic molecules. The polyarginine ...

Subcutaneous injection, Topical

Thymosin Beta-4 Fragment (TB4-Frag)

Recovery
Research Phase

Thymosin Beta-4 Fragment refers to bioactive segments derived from the 43-amino acid thymosin beta-4 protein, most commonly a 7-amino acid N-terminal ...

Subcutaneous injection, Topical

Cathelicidin LL-37 Fragments

Recovery
Research Phase

Cathelicidin LL-37 fragments are truncated sequences derived from the human antimicrobial peptide LL-37, which is a 37-amino acid cleavage product of ...

Topical, Subcutaneous injection

FGL Peptide

Recovery
Research Phase

FGL peptide is a 15-amino acid synthetic sequence derived from the neural cell adhesion molecule (NCAM) that mimics the fibronectin-like domain. It pr...

Subcutaneous injection, Intranasal

GHK (Glycyl-Histidyl-Lysine)

Recovery
Investigational

GHK is a naturally occurring tripeptide with high affinity for copper ions, forming the GHK-Cu complex. It is present in human plasma, saliva, and uri...

Topical, Subcutaneous injection

Matrikine Peptides

Recovery
Research Phase

Matrikine peptides are bioactive fragments released from extracellular matrix proteins during tissue remodeling or injury. These sequences, derived fr...

Topical, Subcutaneous injection

AHK-Cu (Copper Tripeptide-3)

Recovery
Investigational

AHK-Cu is a synthetic copper-binding tripeptide consisting of alanine-histidine-lysine complexed with copper ions. It shares structural and functional...

Topical

Body Protection Compound (BPC) Variants

Recovery
Research Phase

BPC variants are synthetic peptide sequences related to a pentadecapeptide derived from human gastric juice, commonly designated BPC-157. These peptid...

Subcutaneous injection, Oral

Collagen Tripeptide F (CTP-F)

Recovery
Research Phase

Collagen Tripeptide F is a synthetic tripeptide designed to mimic fragments of native collagen that appear during tissue remodeling. It is hypothesize...

Topical, Subcutaneous injection

Sinapultide (KL4 Surfactant)

Recovery
Investigational

Sinapultide is a synthetic 21-amino acid peptide that mimics the structure and function of surfactant protein B, a critical component of pulmonary sur...

Intratracheal instillation

Chrysalin (TP508)

Recovery
Investigational

Chrysalin, also known as TP508, is a 23-amino acid synthetic peptide derived from the receptor-binding domain of human thrombin. It is designed to act...

Topical, Subcutaneous injection

Nexagon (Gap Junction Peptide)

Recovery
In Clinical Trials

Nexagon is a synthetic peptide designed to transiently modulate gap junction intercellular communication by mimicking a segment of the connexin protei...

Topical

OP-1 / BMP-7

Recovery
FDA Approved

OP-1, or osteogenic protein-1, is the recombinant form of bone morphogenetic protein-7 (BMP-7), a member of the transforming growth factor-beta superf...

Implantation at surgical site

Dalargin

Recovery
Investigational

Dalargin is a synthetic hexapeptide analog of leucine-enkephalin with enhanced metabolic stability due to D-amino acid substitutions. It acts as a sel...

Intravenous, Intramuscular injection

Dihexa

Cognitive
Research Phase

Dihexa is a small synthetic hexapeptide derived from angiotensin IV, designed to bind and potentiate hepatocyte growth factor (HGF) signaling through ...

Oral, Subcutaneous injection

NAP (Davunetide)

Cognitive
Investigational

NAP, also known as davunetide, is an eight-amino acid peptide derived from activity-dependent neuroprotective protein (ADNP). It is thought to stabili...

Intranasal

Nemifitide

Cognitive
Investigational

Nemifitide is a synthetic pentapeptide analog of the endogenous neuropeptide alpha-melanocyte-stimulating hormone (alpha-MSH). It acts on melanocortin...

Intravenous

Intranasal Insulin

Cognitive
In Clinical Trials

Intranasal insulin involves the administration of regular human insulin via nasal spray to target central nervous system insulin receptors without cau...

Intranasal

Spadin

Cognitive
Research Phase

Spadin is a 17-amino acid peptide derived from the propeptide released during maturation of sortilin, a neurotensin receptor. It functions as an antag...

Intravenous, Intranasal

Cortexin

Cognitive
In Clinical Trials

Cortexin is a complex polypeptide mixture extracted from bovine cerebral cortex, containing a range of neuropeptides and neurotrophic factors with com...

Intramuscular injection

Pinealon

Cognitive
Investigational

Pinealon is a synthetic tripeptide (Glu-Asp-Arg) developed as part of the Khavinson peptide bioregulator series, designed to mimic endogenous short pe...

Subcutaneous injection, Oral

N-acetyl Semax Amidate

Cognitive
Investigational

N-acetyl Semax Amidate is a modified heptapeptide derivative of adrenocorticotropic hormone (ACTH) fragments, engineered with N-terminal acetylation a...

Intranasal, Subcutaneous injection

N-acetyl Selank Amidate

Cognitive
Investigational

N-acetyl Selank Amidate is a synthetic heptapeptide analog of the immunomodulatory peptide tuftsin, modified with acetylation and amidation to increas...

Intranasal

Bromantane-adjacent Peptides

Cognitive
Research Phase

Bromantane-adjacent peptides refer to a theoretical class of compounds that may share structural or functional motifs with bromantane, a synthetic ada...

Not established

ACTH (4-10) Analogs

Cognitive
Investigational

ACTH (4-10) analogs are synthetic peptides derived from the 4 to 10 amino acid sequence of adrenocorticotropic hormone, engineered to preserve neurotr...

Intranasal, Subcutaneous injection

Orexin A

Cognitive
Research Phase

Orexin A is a 33-amino acid neuropeptide produced in the lateral hypothalamus that plays a critical role in the regulation of wakefulness, arousal, an...

Intracerebroventricular

Orexin B

Cognitive
Research Phase

Orexin B is a 28-amino acid neuropeptide closely related to orexin A, also synthesized in hypothalamic neurons and involved in promoting wakefulness a...

Intracerebroventricular

Neurotensin

Cognitive
Research Phase

Neurotensin is a 13-amino acid neuropeptide widely distributed in the central nervous system and gastrointestinal tract, where it modulates dopaminerg...

Intravenous, Intracerebroventricular

Galanin

Cognitive
Research Phase

Galanin is a 29 or 30 amino acid neuropeptide widely distributed throughout the central and peripheral nervous systems. It acts through three G protei...

Investigational

Argireline (Acetyl Hexapeptide-8)

Dermatology
Investigational

Argireline is a synthetic six amino acid peptide (Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2) designed to attenuate neurotransmitter release at the neuromuscular ...

Topical

Matrixyl (Palmitoyl Pentapeptide-4)

Dermatology
Investigational

Matrixyl is a lipopeptide composed of a pentapeptide sequence (Lys-Thr-Thr-Lys-Ser) attached to a palmitic acid moiety to enhance dermal penetration. ...

Topical

Matrixyl 3000

Dermatology
Investigational

Matrixyl 3000 is a proprietary combination of two lipopeptides: palmitoyl tripeptide-1 (Pal-GHK) and palmitoyl tetrapeptide-7 (Pal-GQPR). The formulat...

Topical

Matrixyl Synthe'6 (Palmitoyl Tripeptide-38)

Dermatology
Investigational

Palmitoyl tripeptide-38 is a synthetic lipopeptide designed to stimulate synthesis of six major constituents of the dermal matrix: collagen I, III, an...

Topical

SYN-AKE (Dipeptide Diaminobutyroyl Benzylamide Diacetate)

Dermatology
Investigational

SYN-AKE is a synthetic dipeptide derivative inspired by the venom peptide waglerin-1 from the Temple viper. It acts as a competitive antagonist at nic...

Topical

SNAP-8 (Acetyl Octapeptide-3)

Dermatology
Investigational

SNAP-8 is an elongated derivative of Argireline, consisting of eight amino acids (Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2) designed to further inhibit ...

Topical

Leuphasyl (Pentapeptide-18)

Dermatology
Investigational

Leuphasyl is a synthetic pentapeptide (Tyr-D-Ala-Gly-Phe-Leu) that mimics the N-terminal sequence of enkephalin and modulates acetylcholine receptor a...

Topical

Vialox (Pentapeptide-3)

Dermatology
Investigational

Vialox is a synthetic pentapeptide designed to modulate neuromuscular signaling by interfering with acetylcholine receptor activation. The exact seque...

Topical

Rigin (Palmitoyl Tetrapeptide-7)

Dermatology
Investigational

Rigin is a lipopeptide composed of the tetrapeptide sequence Gly-Gln-Pro-Arg conjugated to palmitic acid. It is designed to reduce production of inter...

Topical

Biopeptide CL (Palmitoyl Tripeptide-5)

Dermatology
Research Phase

Palmitoyl Tripeptide-5 is a synthetic lipopeptide consisting of a tripeptide sequence conjugated to palmitic acid to enhance dermal penetration. The p...

Topical

Decorinyl (Tripeptide-10 Citrulline)

Dermatology
Research Phase

Decorinyl is a modified tripeptide featuring citrulline substitution, engineered to interact with decorin, a small leucine-rich proteoglycan that regu...

Topical

Haloxyl (Chrysin + Palmitoyl Peptides)

Dermatology
Research Phase

Haloxyl is a combination ingredient consisting of chrysin, a naturally occurring flavone, and palmitoyl oligopeptides designed to address periorbital ...

Topical

Eyeseryl (Acetyl Tetrapeptide-5)

Dermatology
Research Phase

Acetyl Tetrapeptide-5 is a synthetic tetrapeptide modified with an acetyl group to improve stability and cellular uptake. The peptide is proposed to r...

Topical

Trylagen (Tripeptide-10 Complex)

Dermatology
Research Phase

Trylagen is a proprietary complex incorporating Tripeptide-10 Citrulline along with additional bioactive peptides formulated to support collagen and e...

Topical

Myristoyl Pentapeptide-17

Dermatology
Research Phase

Myristoyl Pentapeptide-17 is a lipopeptide composed of a pentapeptide sequence conjugated to myristic acid to facilitate penetration of the hair folli...

Topical

Palmitoyl Tripeptide-1

Dermatology
Research Phase

Palmitoyl Tripeptide-1 is a synthetic lipopeptide comprising a tripeptide linked to palmitic acid, designed to mimic a portion of the Type I collagen ...

Topical

Copper Peptide (Prezatide Copper Acetate)

Dermatology
Research Phase

Prezatide Copper Acetate is a tripeptide-copper complex, most commonly represented by the sequence Gly-His-Lys bound to a copper ion. Copper peptides ...

Topical

Melitane (Acetyl Hexapeptide-1)

Dermatology
Research Phase

Acetyl Hexapeptide-1 is a synthetic hexapeptide designed to stimulate melanin synthesis by acting as an agonist at melanocortin-1 receptors on melanoc...

Topical

Thymogen (Glutamyl-Tryptophan)

Immune
Investigational

Thymogen is a dipeptide consisting of glutamic acid and tryptophan, originally isolated from thymic extracts and proposed to function as an immunomodu...

Subcutaneous injection, Topical

Thymostimulin (TP-1)

Immune
Investigational

Thymostimulin is a polypeptide extract derived from bovine thymus tissue containing multiple biologically active thymic peptides. It acts on T-lymphoc...

Intramuscular injection, Subcutaneous injection

Splenopentin

Immune
Research Phase

Splenopentin is a synthetic pentapeptide (Arg-Lys-Glu-Val-Tyr) corresponding to residues 32 to 36 of the splenic hormone splenin. It modulates immune ...

Subcutaneous injection, Intravenous

Bursin

Immune
Research Phase

Bursin is a tripeptide (Lys-His-Gly) originally isolated from the bursa of Fabricius in avian species. It promotes B-lymphocyte differentiation and im...

Subcutaneous injection

Tuftsin

Immune
Investigational

Tuftsin is a naturally occurring tetrapeptide (Thr-Lys-Pro-Arg) cleaved from the Fc portion of the heavy chain of immunoglobulin G. It binds to specif...

Subcutaneous injection, Intravenous

Imuthiol (Diethyldithiocarbamate)

Immune
Investigational

Imuthiol is the sodium salt of diethyldithiocarbamate, a small molecule rather than a peptide, historically explored for immune modulation and antivir...

Intravenous, Oral

Alpha-MSH

Immune
Research Phase

Alpha-melanocyte-stimulating hormone (alpha-MSH) is a 13-amino-acid peptide derived from proopiomelanocortin (POMC). It acts via melanocortin receptor...

Subcutaneous injection, Intravenous

Beta-Defensin 2

Immune
Research Phase

Beta-defensin 2 (hBD-2) is an antimicrobial peptide of approximately 40 amino acids produced by epithelial cells in response to infection or inflammat...

Topical, Subcutaneous injection

Beta-Defensin 3

Immune
Research Phase

Beta-defensin 3 (hBD-3) is an antimicrobial peptide of approximately 45 amino acids with potent activity against a wide range of pathogens, including ...

Topical, Subcutaneous injection

Granulysin

Immune
Research Phase

Granulysin is a 15-kDa antimicrobial and cytolytic protein expressed by cytotoxic T lymphocytes and natural killer cells. It disrupts microbial and tu...

Intravenous, Subcutaneous injection

Serelaxin (Relaxin-2)

Cardiovascular
Investigational

Serelaxin is a recombinant form of human relaxin-2, a naturally occurring peptide hormone composed of two chains linked by disulfide bonds. It acts vi...

Intravenous

Carperitide (h-ANP)

Cardiovascular
FDA Approved

Carperitide is a recombinant form of human atrial natriuretic peptide consisting of 28 amino acids. It activates guanylyl cyclase A receptors, increas...

Intravenous

Ularitide (Urodilatin)

Cardiovascular
In Clinical Trials

Ularitide is a synthetic 32-amino acid peptide analogue of urodilatin, a natriuretic peptide produced in renal tubular cells. It binds to guanylyl cyc...

Intravenous

Atrial Natriuretic Peptide (ANP)

Cardiovascular
Research Phase

Atrial natriuretic peptide is a 28-amino acid endogenous hormone secreted primarily by atrial cardiomyocytes in response to atrial stretch and volume ...

Endogenous

Brain Natriuretic Peptide (BNP)

Cardiovascular
FDA Approved

Brain natriuretic peptide, despite its name, is a 32-amino acid hormone secreted predominantly by ventricular cardiomyocytes in response to ventricula...

Intravenous

C-type Natriuretic Peptide (CNP)

Cardiovascular
Research Phase

C-type natriuretic peptide is a 22-amino acid member of the natriuretic peptide family that selectively activates natriuretic peptide receptor B (NPR-...

Endogenous

Urocortin 1

Cardiovascular
Investigational

Urocortin 1 is a 40-amino acid peptide belonging to the corticotropin-releasing factor (CRF) family. It binds to both CRF receptor 1 and CRF receptor ...

Intravenous

Urocortin 2

Cardiovascular
Research Phase

Urocortin 2 is a 38-amino acid peptide member of the corticotropin-releasing factor family with selective affinity for CRF receptor 2. It exerts cardi...

Intravenous

Urocortin 3

Cardiovascular
Research Phase

Urocortin 3, also known as stresscopin, is a 38-amino acid peptide with high selectivity for CRF receptor 2. It produces vasodilation and increases ca...

Intravenous

Adrenomedullin

Cardiovascular
Investigational

Adrenomedullin is a 52-amino acid peptide hormone produced by vascular endothelial and smooth muscle cells with potent vasodilatory and natriuretic pr...

Intravenous

Angiotensin (1-7)

Cardiovascular
Investigational

Angiotensin (1-7) is a seven-amino acid peptide component of the renin-angiotensin system formed through cleavage of angiotensin II by ACE2 or from an...

Subcutaneous injection, Intravenous, Oral

Apelin-13

Cardiovascular
Research Phase

Apelin-13 is a 13-amino acid endogenous peptide that represents the most potent and abundant isoform of the apelin family. It acts as the ligand for t...

Intravenous

Degarelix (Firmagon)

Oncology
FDA Approved

Degarelix is a synthetic decapeptide gonadotropin-releasing hormone (GnRH) receptor antagonist used in the treatment of advanced prostate cancer. Unli...

Subcutaneous injection

Triptorelin (Trelstar)

Oncology
FDA Approved

Triptorelin is a synthetic decapeptide analogue of gonadotropin-releasing hormone (GnRH) that functions as a long-acting GnRH agonist. Following an in...

Intramuscular injection

Buserelin (Suprefact)

Oncology
In Clinical Trials

Buserelin is a synthetic nonapeptide analogue of gonadotropin-releasing hormone (GnRH) that acts as a potent GnRH agonist. It binds with high affinity...

Subcutaneous injection, Intranasal

Histrelin (Vantas)

Oncology
FDA Approved

Histrelin is a synthetic nonapeptide analogue of gonadotropin-releasing hormone (GnRH) that functions as a GnRH agonist. The peptide is administered v...

Subcutaneous implant

Abarelix (Plenaxis)

Oncology
FDA Approved

Abarelix is a synthetic decapeptide that functions as a gonadotropin-releasing hormone (GnRH) receptor antagonist. It competitively blocks pituitary G...

Intramuscular injection

Elagolix (Orilissa)

Oncology
FDA Approved

Elagolix is a small molecule non-peptide gonadotropin-releasing hormone (GnRH) receptor antagonist administered orally. While not a peptide itself, it...

Oral

Relugolix (Orgovyx)

Oncology
FDA Approved

Relugolix is an orally bioavailable non-peptide gonadotropin-releasing hormone (GnRH) receptor antagonist. Although it is not a peptide, it exerts its...

Oral

177Lu-PSMA-617 (Pluvicto)

Oncology
FDA Approved

177Lu-PSMA-617 is a radioligand therapeutic consisting of a small peptide-based ligand targeting prostate-specific membrane antigen (PSMA) conjugated ...

Intravenous

Somatostatin (Native)

Oncology
FDA Approved

Somatostatin is a naturally occurring cyclic tetradecapeptide hormone produced by neuroendocrine cells throughout the body, including the hypothalamus...

Intravenous

Vapreotide

Oncology
Investigational

Vapreotide is a synthetic octapeptide analog of somatostatin with enhanced selectivity for somatostatin receptor subtypes 2 and 5. It exerts antisecre...

Subcutaneous injection, Intravenous

Vantictumab

Oncology
In Clinical Trials

Vantictumab is a fully human monoclonal antibody that targets multiple Frizzled receptors involved in the Wnt signaling pathway. By blocking Frizzled ...

Intravenous

Tirbanibulin (Klisyri)

Oncology
FDA Approved

Tirbanibulin is a small molecule synthetic peptide mimetic that inhibits tubulin polymerization and disrupts Src kinase signaling pathways. It is appl...

Topical

Plitidepsin (Aplidin)

Oncology
In Clinical Trials

Plitidepsin is a cyclic depsipeptide originally isolated from the Mediterranean tunicate Aplidium albicans and now produced synthetically. It targets ...

Intravenous

Melphalan Flufenamide (Pepaxto)

Oncology
In Clinical Trials

Melphalan flufenamide is a first-in-class peptide-drug conjugate that links the alkylating agent melphalan to a dipeptide carrier. The dipeptide facil...

Intravenous

Glucagon Receptor Antagonist Peptides

Gastrointestinal
Research Phase

Glucagon receptor antagonist peptides are a class of molecules designed to block the glucagon receptor and prevent glucagon-mediated hepatic glucose o...

Subcutaneous injection

Motilin

Gastrointestinal
Research Phase

Motilin is a 22-amino acid endogenous peptide hormone secreted by enteroendocrine cells in the duodenum and jejunum. It binds to motilin receptors on ...

Intravenous

Cholecystokinin (CCK)

Gastrointestinal
FDA Approved

Cholecystokinin is an endogenous peptide hormone existing in multiple forms, most commonly as CCK-8 and CCK-33, secreted by I-cells in the duodenum an...

Intravenous

Gastrin

Gastrointestinal
Research Phase

Gastrin is an endogenous peptide hormone secreted by G-cells in the gastric antrum and duodenum, existing primarily as gastrin-17 and gastrin-34. It b...

Subcutaneous injection, Intravenous

Peptide YY (PYY 3-36)

Gastrointestinal
In Clinical Trials

Peptide YY 3-36 is a 34-amino acid endogenous peptide hormone secreted by L-cells in the distal small intestine and colon in response to nutrient inta...

Intravenous, Intranasal

Ghrelin Receptor Antagonists

Gastrointestinal
In Clinical Trials

Ghrelin receptor antagonists are a class of peptides and peptidomimetics designed to block the growth hormone secretagogue receptor (GHSR), also known...

Subcutaneous injection, Oral

Guanylin

Gastrointestinal
Research Phase

Guanylin is a 15-amino acid endogenous peptide hormone that activates guanylate cyclase-C (GC-C) receptors on intestinal epithelial cells. Upon bindin...

Endogenous peptide

Uroguanylin (Dolcanatide)

Gastrointestinal
In Clinical Trials

Uroguanylin is a 16-amino acid endogenous peptide structurally related to guanylin that also activates guanylate cyclase-C receptors in the intestinal...

Oral

Dynorphin A

Pain
Research Phase

Dynorphin A is an endogenous opioid peptide of 17 amino acids that preferentially binds to and activates kappa-opioid receptors, though it also has af...

Endogenous peptide

Leu-Enkephalin

Pain
Research Phase

Leu-enkephalin is a pentapeptide (Tyr-Gly-Gly-Phe-Leu) that functions as an endogenous opioid agonist with preferential activity at delta-opioid recep...

Endogenous peptide

Met-Enkephalin

Pain
Research Phase

Met-enkephalin is a pentapeptide (Tyr-Gly-Gly-Phe-Met) that differs from leu-enkephalin only in its C-terminal amino acid. It acts as an endogenous op...

Endogenous peptide

Endomorphin-1

Pain
Research Phase

Endomorphin-1 is a tetrapeptide (Tyr-Pro-Trp-Phe) that exhibits highly selective agonist activity at the mu-opioid receptor, the primary target for an...

Endogenous peptide

Endomorphin-2

Pain
Research Phase

Endomorphin-2 is a tetrapeptide (Tyr-Pro-Phe-Phe) that, like endomorphin-1, demonstrates highly selective agonism at mu-opioid receptors. The two endo...

Endogenous peptide

Nociceptin / Orphanin FQ

Pain
Research Phase

Nociceptin, also known as orphanin FQ, is a 17-amino acid peptide that acts as the endogenous ligand for the nociceptin/orphanin FQ peptide (NOP) rece...

Endogenous peptide

Conantokin-G

Pain
Investigational

Conantokin-G is a 17-amino acid peptide originally isolated from the venom of the cone snail Conus geographus. It acts as a selective antagonist of N-...

Intrathecal, Intravenous

Dermorphin

Pain
Research Phase

Dermorphin is a heptapeptide opioid agonist originally isolated from the skin of South American Phyllomedusa frogs. It exhibits high selectivity and a...

Intracerebroventricular, Subcutaneous injection

Deltorphin

Pain
Research Phase

Deltorphin is a heptapeptide opioid agonist also derived from Phyllomedusa frog skin secretions, characterized by high selectivity for delta-opioid re...

Intracerebroventricular, Subcutaneous injection

Neuropeptide FF

Pain
Research Phase

Neuropeptide FF (NPFF) is an octapeptide belonging to the RFamide family, characterized by an arginine-phenylalanine-amide motif at the C-terminus. It...

Intracerebroventricular, Subcutaneous injection

Magainin 2

Antimicrobial
Research Phase

Magainin 2 is a 23-amino acid antimicrobial peptide originally isolated from the skin of the African clawed frog Xenopus laevis. It exerts broad-spect...

Topical

Pexiganan (MSI-78)

Antimicrobial
In Clinical Trials

Pexiganan is a 22-amino acid synthetic analog of magainin 2 designed to enhance antimicrobial potency and proteolytic stability. It disrupts bacterial...

Topical

Omiganan

Antimicrobial
In Clinical Trials

Omiganan is a synthetic 12-amino acid cationic antimicrobial peptide derived from indolicidin, a naturally occurring peptide from bovine neutrophils. ...

Topical

Iseganan (IB-367)

Antimicrobial
Investigational

Iseganan is a 17-amino acid synthetic analog of protegrin, a naturally occurring antimicrobial peptide found in porcine leukocytes. It disrupts microb...

Oral rinse

Defensin HNP-1

Antimicrobial
Research Phase

Human neutrophil peptide 1 (HNP-1) is a 30-amino acid alpha-defensin produced by neutrophils as part of the innate immune response. It contains three ...

Topical, Intravenous

Alpha-Defensin 5

Antimicrobial
Research Phase

Alpha-defensin 5 (HD5) is a 32-amino acid cationic peptide predominantly expressed by Paneth cells in the small intestinal crypts. It contains three d...

Oral, Topical

Lactoferricin

Antimicrobial
Investigational

Lactoferricin is a cationic antimicrobial peptide derived from pepsin-mediated cleavage of lactoferrin, an iron-binding glycoprotein found in milk and...

Oral, Topical

Nisin

Antimicrobial
Investigational

Nisin is a 34-amino acid polycyclic antibacterial peptide (lantibiotic) produced by Lactococcus lactis. It disrupts bacterial cell wall synthesis and ...

Topical, Oral

Gramicidin S

Antimicrobial
Investigational

Gramicidin S is a cyclic decapeptide antibiotic isolated from Bacillus brevis, consisting of two identical pentapeptide sequences joined in a ring str...

Topical

Polymyxin B

Antimicrobial
FDA Approved

Polymyxin B is a cyclic lipopeptide antibiotic derived from Bacillus polymyxa, consisting of a heptapeptide ring and a tripeptide side chain acylated ...

Intravenous, Intrathecal, Topical

Colistin (Polymyxin E)

Antimicrobial
FDA Approved

Colistin, also known as polymyxin E, is a cyclic polypeptide antibiotic structurally similar to polymyxin B, produced by Paenibacillus polymyxa. It di...

Intravenous, Intramuscular, Inhalation

Indolicidin

Antimicrobial
Research Phase

Indolicidin is a 13-amino acid antimicrobial peptide derived from bovine neutrophils, characterized by a high tryptophan content (five residues). It e...

Topical

PTH (1-34) Analogs

Bone
FDA Approved

PTH (1-34) analogs, including teriparatide and abaloparatide, are synthetic peptides corresponding to the 34 N-terminal amino acids of human parathyro...

Subcutaneous injection

Sclerostin Antibodies (Romosozumab)

Bone
FDA Approved

Romosozumab is a humanized monoclonal antibody that binds and inhibits sclerostin, a glycoprotein produced by osteocytes that negatively regulates the...

Subcutaneous injection

Osteogenic Growth Peptide (OGP)

Bone
Research Phase

Osteogenic Growth Peptide is a naturally occurring 14-amino acid peptide identified in serum that promotes osteoblast proliferation and differentiatio...

Subcutaneous injection

BMP-2 (Bone Morphogenetic Protein-2)

Bone
FDA Approved

BMP-2 is a member of the transforming growth factor-beta superfamily, consisting of a homodimeric protein with each monomer containing approximately 1...

Surgical implantation

BMP-7 (Osteogenic Protein-1)

Bone
FDA Approved

BMP-7, also known as osteogenic protein-1 (OP-1), is a member of the bone morphogenetic protein family with a mature homodimeric structure of approxim...

Surgical implantation

Calcitonin Gene-Related Peptide (CGRP)

Bone
Research Phase

Calcitonin gene-related peptide is a 37-amino acid neuropeptide produced by alternative splicing of the calcitonin gene. CGRP acts as a potent vasodil...

Intravenous, Subcutaneous injection

Gonadotropin Releasing Hormone (GnRH) Agonists

Longevity
FDA Approved

Gonadotropin-releasing hormone agonists are synthetic decapeptide analogues of native GnRH that initially stimulate and then suppress gonadotropin sec...

Subcutaneous injection, Intramuscular injection, Subcutaneous implant, Intranasal

Klotho Peptide

Longevity
Research Phase

Klotho is a transmembrane protein of approximately 1012 amino acids that exists in membrane-bound and secreted forms, with the soluble ectodomain func...

Intravenous

Sirtuin-Activating Peptides

Longevity
Research Phase

Sirtuin-activating peptides represent a class of investigational compounds designed to enhance the enzymatic activity of sirtuins, a family of NAD-dep...

Subcutaneous injection

Mitochondrial-Targeted Peptides (MTP)

Longevity
In Clinical Trials

Mitochondrial-targeted peptides are short synthetic sequences, typically 2 to 8 amino acids, designed to localize to mitochondria and protect against ...

Subcutaneous injection, Intravenous

Thymulin (Zn-FTS)

Longevity
Investigational

Thymulin is a nonapeptide hormone secreted by thymic epithelial cells that requires zinc for biological activity and is also referred to as facteur th...

Subcutaneous injection

Gerontin (Pineal Gland Extract)

Longevity
Investigational

Gerontin refers to peptide fractions derived from pineal gland extracts studied primarily in Russian gerontology research. These preparations are hypo...

Subcutaneous injection

Vilon (Lys-Glu)

Longevity
Investigational

Vilon is a synthetic dipeptide consisting of lysine and glutamic acid (Lys-Glu) developed as part of the Khavinson bioregulator peptide research progr...

Subcutaneous injection, Oral

Bioregulator Peptides (Khavinson)

Longevity
Investigational

Bioregulator peptides are a class of short synthetic peptides, typically 2 to 4 amino acids in length, developed by Russian researcher Vladimir Khavin...

Subcutaneous injection, Oral, Intramuscular injection

IGF-1 LR3 (Long-Arg3)

Performance
Research Phase

IGF-1 LR3 is a synthetic analogue of insulin-like growth factor 1 with an N-terminal extension of 13 amino acids and a substitution of arginine for gl...

Subcutaneous injection

IGF-1 DES (1-3)

Performance
Research Phase

IGF-1 DES (1-3) is a truncated analogue of insulin-like growth factor 1 lacking the first three N-terminal amino acids (glycine-proline-glutamate). Th...

Subcutaneous injection

MGF (Mechano Growth Factor)

Performance
Research Phase

Mechano Growth Factor is a splice variant of the IGF-1 gene expressed in response to mechanical stress on muscle tissue. The peptide contains a unique...

Intramuscular injection

PEG-MGF

Performance
Research Phase

PEG-MGF is a pegylated derivative of Mechano Growth Factor designed to extend systemic half-life through the addition of polyethylene glycol moieties....

Subcutaneous injection

Follistatin-344

Performance
Research Phase

Follistatin-344 is a 344-amino acid glycoprotein that functions as a binding protein and endogenous antagonist of myostatin and other members of the T...

Intramuscular injection, Gene delivery

ACE-031 (Ramatercept)

Performance
Investigational

ACE-031 is a recombinant fusion protein combining the extracellular domain of the activin receptor type IIB with a human IgG1 Fc domain. This soluble ...

Subcutaneous injection

Nafarelin (Synarel)

Reproductive
FDA Approved

Nafarelin is a synthetic decapeptide analogue of gonadotropin-releasing hormone (GnRH) with substitutions at positions 6 and 10 that enhance receptor ...

Intranasal

Choriogonadotropin Alfa (Ovidrel)

Reproductive
FDA Approved

Choriogonadotropin alfa is a recombinant human chorionic gonadotropin produced in Chinese hamster ovary cells with identical amino acid sequence to en...

Subcutaneous injection

Follitropin Alfa (Gonal-F)

Reproductive
FDA Approved

Follitropin alfa is a recombinant human follicle-stimulating hormone produced in Chinese hamster ovary cells, consisting of a heterodimeric glycoprote...

Subcutaneous injection

Menotropin (Menopur)

Reproductive
FDA Approved

Menotropin is a purified preparation of human menopausal gonadotropins extracted from the urine of postmenopausal women, containing both follicle-stim...

Subcutaneous injection, Intramuscular injection

Corifollitropin Alfa (Elonva)

Reproductive
FDA Approved

Corifollitropin alfa is a recombinant long-acting FSH analogue created by fusing the C-terminal peptide of the hCG beta subunit to the FSH beta chain....

Subcutaneous injection

Cetrorelix (Cetrotide) Analog

Reproductive
FDA Approved

Cetrorelix is a synthetic decapeptide analog of gonadotropin-releasing hormone (GnRH) that acts as a competitive GnRH receptor antagonist. By binding ...

Subcutaneous injection

Peginesatide (Omontys)

Hematology
FDA Approved

Peginesatide is a synthetic pegylated peptide-based erythropoiesis-stimulating agent (ESA) consisting of two 21-amino acid chains linked to polyethyle...

Intravenous, Subcutaneous injection

Eltrombopag Peptide Mimetics

Hematology
FDA Approved

Eltrombopag is a small-molecule, non-peptide thrombopoietin receptor agonist that binds to the transmembrane domain of the thrombopoietin receptor, di...

Oral

Hepcidin

Hematology
In Clinical Trials

Hepcidin is a 25-amino acid endogenous peptide hormone produced primarily by hepatocytes that serves as the master regulator of systemic iron homeosta...

Subcutaneous injection

Thrombopoietin (TPO)

Hematology
Investigational

Thrombopoietin is a 332-amino acid endogenous glycoprotein hormone and the primary physiologic regulator of megakaryopoiesis and platelet production. ...

Subcutaneous injection, Intravenous

Gadopentetate Peptide Conjugates

Diagnostic
Research Phase

Gadopentetate peptide conjugates consist of the gadolinium-based contrast agent gadopentetate dimeglumine chemically linked to targeting peptides desi...

Intravenous

DOTATATE (Ga-68)

Diagnostic
FDA Approved

Gallium-68 DOTATATE is a radiolabeled somatostatin analog consisting of an octapeptide (Tyr3-octreotate) conjugated to the macrocyclic chelator DOTA, ...

Intravenous

Bombesin Analog Tracers

Diagnostic
In Clinical Trials

Bombesin analog tracers are synthetic peptides based on the 14-amino acid amphibian peptide bombesin or its mammalian counterpart gastrin-releasing pe...

Intravenous

RGD Peptide Tracers

Diagnostic
In Clinical Trials

RGD peptide tracers are short synthetic peptides containing the arginine-glycine-aspartic acid (RGD) tripeptide sequence, which binds to integrin rece...

Intravenous

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Research Sources & Disclaimer

Data in this database is compiled from peer-reviewed literature indexed on PubMed / MEDLINE, clinical trial registries at ClinicalTrials.gov, and drug monographs from the National Institutes of Health (NIH) and FDA drug approval databases. Regulatory status reflects U.S. FDA classification unless otherwise noted.

This database is for educational and informational purposes only and does not constitute medical advice. Many peptides listed are investigational and not approved for clinical use. Consult a qualified healthcare provider before considering any peptide therapy. Research status and findings are current as of early 2026 and subject to change as new data emerges.