DermatologyResearch Phase

Eyeseryl (Acetyl Tetrapeptide-5)

Overview

Acetyl Tetrapeptide-5 is a synthetic tetrapeptide modified with an acetyl group to improve stability and cellular uptake. The peptide is proposed to reduce periorbital edema by modulating capillary permeability and enhancing lymphatic drainage, potentially through downregulation of pro-inflammatory cytokines such as interleukin-1. Its application is focused on reduction of under-eye puffiness and fluid accumulation.

Key Research Findings

In vitro studies on endothelial cell monolayers have demonstrated reduced permeability and decreased inflammatory marker expression. A small clinical trial reported subjective improvement in periorbital edema after four weeks, though the study lacked control groups and has not been reproduced in major peer-reviewed dermatology journals.

Route of Administration

Topical

Regulatory Status

Research Phase

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