Leuphasyl (Pentapeptide-18)
Overview
Leuphasyl is a synthetic pentapeptide (Tyr-D-Ala-Gly-Phe-Leu) that mimics the N-terminal sequence of enkephalin and modulates acetylcholine receptor activity at the neuromuscular junction. It is proposed to stabilize the receptor in an inactive conformation, reducing the frequency of muscle fiber contraction without blocking neurotransmission. This mechanism is intended to yield a topical wrinkle-smoothing effect with cosmetic applications.
Key Research Findings
In vitro electrophysiology studies have shown that pentapeptide-18 reduces the amplitude of miniature endplate potentials in muscle preparations. Industry-supported trials have reported subjective improvements in periorbital and forehead lines after four weeks of topical use, though rigorous placebo-controlled designs and independent validation are limited. Clinical evidence in peer-reviewed dermatology literature remains sparse.
Topical
Investigational
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