Rigin (Palmitoyl Tetrapeptide-7)
Overview
Rigin is a lipopeptide composed of the tetrapeptide sequence Gly-Gln-Pro-Arg conjugated to palmitic acid. It is designed to reduce production of interleukin-6 and other pro-inflammatory cytokines in dermal fibroblasts, thereby mitigating chronic low-grade inflammation associated with skin aging. By modulating the inflammatory microenvironment, the peptide is proposed to support matrix integrity and reduce glycation-induced damage.
Key Research Findings
In vitro studies using UV-irradiated or cytokine-stimulated fibroblasts have demonstrated that palmitoyl tetrapeptide-7 reduces IL-6 secretion and restores collagen synthesis. Industry-sponsored trials, often in combination with palmitoyl tripeptide-1 (Matrixyl 3000), have reported improvements in skin firmness and wrinkle depth, though isolated effects of Rigin are not well characterized. Independent peer-reviewed clinical data remain limited.
Topical
Investigational
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InvestigationalMatrixyl is a lipopeptide composed of a pentapeptide sequence (Lys-Thr-Thr-Lys-Ser) attached to a palmitic acid moiety to enhance dermal penetration. It is proposed to stimulate fibroblast activity and upregulate synthesis of extracellular matrix components including collagen types I and III, fibronectin, and hyaluronic acid. The peptide serves as a matrikine fragment mimetic, signaling tissue remodeling pathways in aged or photodamaged skin.
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