Pramlintide (Symlin)
Overview
A synthetic analog of amylin (islet amyloid polypeptide), a 37-amino acid peptide hormone co-secreted with insulin from pancreatic beta cells. Pramlintide has three proline substitutions that prevent amyloid fibril formation while retaining amylin receptor activity. It slows gastric emptying, suppresses postprandial glucagon secretion, and promotes satiety via area postrema activation, complementing insulin therapy in diabetes management.
Key Research Findings
FDA-approved in 2005 as adjunct to insulin therapy in type 1 and type 2 diabetes. Clinical trials showed 0.3-0.6% additional HbA1c reduction and 1-2 kg weight loss when added to insulin. Reduces postprandial glucose excursions by 50% through delayed gastric emptying and glucagon suppression.
Subcutaneous injection (before meals)
FDA Approved
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