AOD-9604
Overview
A modified 16-amino acid fragment (amino acids 176-191) of the C-terminus of human growth hormone with an added tyrosine at the N-terminus. AOD-9604 retains the lipolytic activity of hGH without its growth-promoting or diabetogenic effects. It stimulates lipolysis and inhibits lipogenesis through a mechanism distinct from the GH receptor, acting on beta-3 adrenergic receptors in adipose tissue.
Key Research Findings
Preclinical studies showed significant fat reduction without effects on IGF-1, glucose, or insulin levels. Phase 2b clinical trial showed modest but statistically significant weight reduction. TGA (Australia) approved as a food supplement. Limited Phase 3 clinical evidence.
Subcutaneous injection, Oral
Investigational
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