Ecnoglutide
Overview
Ecnoglutide is a long-acting GLP-1 receptor agonist peptide designed for once-weekly subcutaneous administration. It acts by enhancing glucose-dependent insulin secretion, reducing glucagon levels, and delaying gastric emptying to improve glycemic control and promote weight loss. The extended half-life is achieved through structural modifications that resist enzymatic degradation and renal clearance.
Key Research Findings
Phase 2 trials in adults with type 2 diabetes have demonstrated reductions in HbA1c and body weight consistent with the GLP-1 agonist class. Safety data showed a typical profile of gastrointestinal adverse events. Further development is needed to establish positioning relative to existing long-acting GLP-1 therapies.
Subcutaneous injection
In Clinical Trials
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