GastrointestinalFDA Approved

Secretin

Intravenous

Overview

A 27-amino acid peptide hormone produced by S-cells of the duodenal and jejunal mucosa in response to acidic chyme entering the small intestine. Secretin stimulates pancreatic ductal cells to secrete bicarbonate-rich fluid, neutralizing duodenal acid, and promotes bile flow from hepatocytes.

Mechanism of Action

It was the first hormone ever identified (Bayliss and Starling, 1902) and serves as a key diagnostic tool in gastroenterology and endocrinology..

Research Summary & Key Findings

FDA-approved as a diagnostic agent for pancreatic exocrine function (secretin stimulation test), gastrinoma/Zollinger-Ellison syndrome diagnosis (paradoxical gastrin rise), and to facilitate MRCP imaging of pancreatic ducts. Synthetic human secretin (ChiRhoStim/SecreFlo) replaced porcine-derived products. Investigated but not proven effective as a treatment for autism spectrum disorder despite initial case reports.

Clinical Status

FDA Approved

Secretin has received FDA approval and is available for clinical use under appropriate medical supervision. Consult a qualified healthcare provider for prescribing information.

Administration Routes

Intravenous

Related Peptides in Gastrointestinal

Octreotide (Sandostatin)

FDA Approved

A synthetic octapeptide analog of somatostatin with a substantially longer half-life (90 minutes IV, 6 hours subcutaneou...

View details

Lanreotide (Somatuline Depot)

FDA Approved

A synthetic octapeptide analog of somatostatin with high affinity for SSTR2 and moderate affinity for SSTR5 receptors. L...

View details

Pasireotide (Signifor)

FDA Approved

A multireceptor-targeted somatostatin analog with high binding affinity for SSTR1, SSTR2, SSTR3, and SSTR5, particularly...

View details

Plecanatide (Trulance)

FDA Approved

A synthetic 16-amino acid peptide structurally related to uroguanylin, an endogenous intestinal peptide that regulates f...

View details

Find a Provider

Find a verified provider who offers Secretin therapy in your area.

Browse Provider Map

Find a Pharmacy

Browse PCAB-accredited and FDA 503B-registered compounding pharmacies that supply Secretin.

Pharmacy Directory

Join the Association

Access exclusive peptide protocols, provider resources, and community support.

List Your Practice

Disclaimer: This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide therapy. The Peptide Association does not endorse or recommend any specific treatment protocol.