GastrointestinalFDA Approved

Octreotide (Sandostatin)

Subcutaneous injection, Intramuscular injection (LAR), Intravenous

Overview

A synthetic octapeptide analog of somatostatin with a substantially longer half-life (90 minutes IV, 6 hours subcutaneous vs. 2 minutes for native somatostatin).

Mechanism of Action

Octreotide binds somatostatin receptors (primarily SSTR2 and SSTR5) to inhibit the secretion of GH, glucagon, insulin, gastrin, secretin, VIP, and other GI hormones. It reduces splanchnic blood flow, GI motility, and exocrine pancreatic secretion..

Research Summary & Key Findings

FDA-approved for acromegaly, carcinoid syndrome (diarrhea/flushing), and VIPoma-associated watery diarrhea. Long-acting release (LAR) formulation provides once-monthly dosing. PROMID trial showed antiproliferative effect in midgut neuroendocrine tumors with 66% risk reduction for disease progression (Rinke et al., J Clin Oncol, 2009). Used off-label for variceal bleeding, pancreatic fistula, and refractory diarrhea.

Clinical Status

FDA Approved

Octreotide (Sandostatin) has received FDA approval and is available for clinical use under appropriate medical supervision. Consult a qualified healthcare provider for prescribing information.

Administration Routes

Subcutaneous injectionIntramuscular injection (LAR)Intravenous

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Disclaimer: This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide therapy. The Peptide Association does not endorse or recommend any specific treatment protocol.