GastrointestinalFDA Approved

Lanreotide (Somatuline Depot)

Deep subcutaneous injection (monthly)

Overview

A synthetic octapeptide analog of somatostatin with high affinity for SSTR2 and moderate affinity for SSTR5 receptors. Lanreotide is formulated as a supersaturated solution that forms a drug depot at the injection site, providing sustained release over 4 weeks.

Mechanism of Action

It inhibits GH secretion, GI hormone release, and has direct antiproliferative effects on neuroendocrine tumor cells through cell cycle arrest and apoptosis induction..

Research Summary & Key Findings

FDA-approved for acromegaly and gastroenteropancreatic neuroendocrine tumors (GEP-NETs). CLARINET trial demonstrated significant antiproliferative effect in nonfunctioning GEP-NETs with median PFS not reached vs. 18 months for placebo (Caplin et al., NEJM, 2014). Deep subcutaneous injection by patient or caregiver allows home administration. Comparable efficacy to octreotide LAR with improved convenience.

Clinical Status

FDA Approved

Lanreotide (Somatuline Depot) has received FDA approval and is available for clinical use under appropriate medical supervision. Consult a qualified healthcare provider for prescribing information.

Administration Routes

Deep subcutaneous injection (monthly)

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Disclaimer: This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide therapy. The Peptide Association does not endorse or recommend any specific treatment protocol.