HematologyFDA Approved

Romiplostim (Nplate)

Subcutaneous injection (weekly)

Overview

A thrombopoietin (TPO) receptor agonist consisting of a peptide sequence that binds the TPO receptor (c-Mpl) fused to an IgG1 Fc domain (peptibody). Romiplostim activates JAK2/STAT5 signaling in megakaryocyte progenitors, promoting megakaryocyte proliferation, differentiation, and platelet production.

Mechanism of Action

It has no sequence homology to endogenous TPO, minimizing the risk of cross-reactive antibody formation..

Research Summary & Key Findings

FDA-approved in 2008 for chronic immune thrombocytopenia (ITP) in adults with insufficient response to corticosteroids, immunoglobulins, or splenectomy. Clinical trials showed durable platelet responses in 79-88% of patients with splenectomized and non-splenectomized ITP. Extended treatment studies demonstrated sustained platelet response for up to 5 years. Risk of bone marrow reticulin fiber deposition requires monitoring.

Clinical Status

FDA Approved

Romiplostim (Nplate) has received FDA approval and is available for clinical use under appropriate medical supervision. Consult a qualified healthcare provider for prescribing information.

Administration Routes

Subcutaneous injection (weekly)

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Disclaimer: This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide therapy. The Peptide Association does not endorse or recommend any specific treatment protocol.