HematologyFDA Approved

Bivalirudin (Angiomax)

Intravenous

Overview

A synthetic 20-amino acid peptide that acts as a direct thrombin inhibitor by binding both the catalytic active site and anion-binding exosite 1 of thrombin. Bivalirudin inhibits both free and clot-bound thrombin, providing more predictable anticoagulation than heparin without requiring antithrombin III as a cofactor.

Mechanism of Action

It is enzymatically cleaved by thrombin itself, producing a self-limiting anticoagulant effect with a 25-minute half-life..

Research Summary & Key Findings

FDA-approved for use in percutaneous coronary intervention (PCI) and as an anticoagulant in patients with or at risk of heparin-induced thrombocytopenia (HIT). HORIZONS-AMI trial showed reduced major bleeding and 30-day mortality vs. heparin plus GP IIb/IIIa inhibitors in primary PCI for STEMI. Does not cause immune-mediated thrombocytopenia. Widely used as an alternative to heparin in the cardiac catheterization lab.

Clinical Status

FDA Approved

Bivalirudin (Angiomax) has received FDA approval and is available for clinical use under appropriate medical supervision. Consult a qualified healthcare provider for prescribing information.

Administration Routes

Intravenous

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Disclaimer: This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide therapy. The Peptide Association does not endorse or recommend any specific treatment protocol.