Guanylin
Overview
Guanylin is a 15-amino acid endogenous peptide hormone that activates guanylate cyclase-C (GC-C) receptors on intestinal epithelial cells. Upon binding, it stimulates intracellular cyclic GMP production, which regulates chloride and bicarbonate secretion into the intestinal lumen and promotes fluid secretion.
Mechanism of Action
This mechanism enhances intestinal motility and fluid balance. Guanylin functions as a paracrine regulator of intestinal homeostasis and salt-water equilibrium..
Research Summary & Key Findings
Guanylin itself has been characterized primarily in preclinical studies elucidating its role in intestinal fluid regulation and epithelial cell function. Synthetic analogs of guanylin, such as linaclotide and plecanatide, have been developed and approved for clinical use in chronic constipation and irritable bowel syndrome with constipation. Native guanylin remains a research tool rather than a therapeutic agent.
Clinical Status
Guanylin is in the research phase with limited clinical data in humans. Current evidence is primarily derived from preclinical (animal or in vitro) studies.
Administration Routes
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