GastrointestinalFDA Approved

Cholecystokinin (CCK)

Intravenous

Overview

Cholecystokinin is an endogenous peptide hormone existing in multiple forms, most commonly as CCK-8 and CCK-33, secreted by I-cells in the duodenum and jejunum. It binds to CCK-1 and CCK-2 receptors to stimulate gallbladder contraction, pancreatic enzyme secretion, and satiety signaling.

Mechanism of Action

Therapeutic interest centers on diagnostic imaging applications and potential treatments for obesity and functional gastrointestinal disorders. The peptide also plays neuromodulatory roles in the central nervous system..

Research Summary & Key Findings

Sincalide, a synthetic CCK-8 analog, is FDA approved for diagnostic use to stimulate gallbladder contraction during cholescintigraphy and to stimulate pancreatic secretion for sample collection. Clinical trials exploring CCK analogs for obesity have shown limited efficacy due to rapid desensitization and gastrointestinal side effects. Research continues into selective CCK receptor modulation for metabolic and gastrointestinal applications.

Clinical Status

FDA Approved

Cholecystokinin (CCK) has received FDA approval and is available for clinical use under appropriate medical supervision. Consult a qualified healthcare provider for prescribing information.

Administration Routes

Intravenous

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Disclaimer: This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide therapy. The Peptide Association does not endorse or recommend any specific treatment protocol.