DSIP (Delta Sleep-Inducing Peptide)
Overview
A naturally occurring nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) originally isolated from cerebral venous blood of rabbits during induced sleep. DSIP modulates sleep architecture by promoting delta wave (slow-wave) sleep through interactions with the GABAergic system and hypothalamic sleep centers. It also exhibits stress-protective, analgesic, and neuromodulatory properties.
Key Research Findings
Clinical studies showed normalization of disturbed sleep patterns in insomnia patients without next-day sedation. Demonstrated reduction in stress-related corticotropin levels. Limited clinical data but preclinical models show consistent sleep-promoting and neuroprotective effects.
Subcutaneous injection, Intravenous, Intranasal
Research Phase
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