CognitiveResearch Phase

Dihexa

Overview

Dihexa is a small synthetic hexapeptide derived from angiotensin IV, designed to bind and potentiate hepatocyte growth factor (HGF) signaling through the c-Met receptor. This action is hypothesized to promote synaptogenesis, dendritic spine formation, and neuronal survival in models of cognitive impairment. Dihexa exhibits high oral bioavailability and blood-brain barrier penetration due to its small size and lipophilic character.

Key Research Findings

Preclinical studies in rodent models of Alzheimer disease and traumatic brain injury have demonstrated improvements in spatial learning and memory consolidation. No human clinical trials have been published in peer-reviewed journals, and safety and efficacy data in humans remain absent.

Route of Administration

Oral, Subcutaneous injection

Regulatory Status

Research Phase

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