Cerebrolysin
Overview
A porcine brain-derived peptide preparation consisting of low-molecular-weight neuropeptides and free amino acids that mimic the action of endogenous neurotrophic factors. Cerebrolysin exhibits neurotrophic activity similar to BDNF, GDNF, and CNTF, promoting neuronal survival, synaptic plasticity, and neurogenesis. It modulates GSK-3beta, CDK5, and calcineurin-NFAT signaling cascades involved in neurodegeneration.
Key Research Findings
Approved in over 50 countries (not FDA-approved) for stroke, traumatic brain injury, and Alzheimer's disease. A meta-analysis of clinical trials showed modest improvements in global clinical function in Alzheimer's patients (Gauthier et al., Dement Geriatr Cogn Disord, 2015). The CASTA trial in acute ischemic stroke showed improved outcomes at 90 days. Safety concerns regarding prion transmission from porcine brain tissue have been raised but not substantiated.
Intravenous, Intramuscular injection
Investigational
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