Cotadutide
Overview
Cotadutide is a dual agonist of the GLP-1 and glucagon receptors formulated as a peptide for subcutaneous injection. It is designed to harness GLP-1-mediated improvements in glucose homeostasis and satiety alongside glucagon receptor activation to enhance energy expenditure and reduce hepatic fat. Primary indications under investigation include obesity, type 2 diabetes, and metabolic dysfunction-associated steatohepatitis.
Key Research Findings
Phase 2 studies in patients with type 2 diabetes and non-alcoholic fatty liver disease showed reductions in body weight and liver fat. Data presented at liver and diabetes conferences in 2019 and 2020 supported continued investigation. Development status and phase 3 plans have not been widely updated in recent literature.
Subcutaneous injection
In Clinical Trials
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