Cortexin
Overview
Cortexin is a complex polypeptide mixture extracted from bovine cerebral cortex, containing a range of neuropeptides and neurotrophic factors with combined molecular weights below 10 kDa. The preparation is proposed to exert neurotrophic and neuroprotective effects by modulating glutamatergic transmission, reducing oxidative stress, and supporting synaptic function. It has been used primarily in Russia and Eastern Europe for cognitive and neurological indications.
Key Research Findings
Multiple open-label and controlled trials published in regional neurology journals have reported improvements in cognitive outcomes following stroke, traumatic brain injury, and cognitive impairment, although methodological quality and replication in Western literature remain limited. The heterogeneous peptide composition complicates mechanistic validation and regulatory assessment. Clinical use remains largely confined to post-Soviet healthcare systems.
Intramuscular injection
In Clinical Trials
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