Apraglutide
Overview
Apraglutide is a long-acting glucagon-like peptide-2 (GLP-2) receptor agonist designed to promote intestinal growth and improve absorption in patients with short bowel syndrome. The peptide analogue shares structural homology with native GLP-2 but incorporates modifications that extend its half-life and enhance resistance to dipeptidyl peptidase-4 degradation. By binding to GLP-2 receptors in the intestinal epithelium, apraglutide stimulates crypt cell proliferation and reduces gastric emptying and secretion, supporting adaptive intestinal function.
Key Research Findings
Phase 3 trials in adults with short bowel syndrome dependent on parenteral support have demonstrated significant reductions in parenteral nutrition volume requirements compared to placebo. The compound has been studied primarily in patients with remnant colon or jejunostomy configurations, with published data appearing in Gastroenterology and related specialty journals since 2020.
Subcutaneous injection
In Clinical Trials
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