HormoneFDA Approved

Somapacitan (Sogroya)

Subcutaneous injection

Overview

Somapacitan is a long-acting growth hormone analogue engineered by attaching an albumin-binding moiety to recombinant human growth hormone. This modification extends the half-life to allow once-weekly subcutaneous administration, compared to daily injections required for standard somatropin.

Mechanism of Action

The peptide retains growth hormone receptor agonist activity with pharmacokinetic enhancement intended to improve treatment adherence..

Research Summary & Key Findings

The REAL 1 trial (Journal of Clinical Endocrinology and Metabolism, 2020) demonstrated non-inferiority to daily somatropin in adult growth hormone deficiency, leading to FDA approval in August 2020. The REAL 2 trial confirmed efficacy in treatment-naïve adults with similar outcomes. Somapacitan represents the first once-weekly growth hormone replacement therapy approved in the United States.

Clinical Status

FDA Approved

Somapacitan (Sogroya) has received FDA approval and is available for clinical use under appropriate medical supervision. Consult a qualified healthcare provider for prescribing information.

Administration Routes

Subcutaneous injection

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Disclaimer: This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide therapy. The Peptide Association does not endorse or recommend any specific treatment protocol.