Sirtuin-Activating Peptides

Sirtuin-activating peptides represent a class of investigational compounds designed to enhance the enzymatic activity of sirtuins, a family of NAD-dependent deacetylases implicated in longevity and metabolic regulation. These peptides aim to mimic or potentiate the effects of caloric restriction by modulating histone deacetylation, mitochondrial biogenesis, and stress resistance pathways.

While small molecule sirtuin activators such as resveratrol analogues have received more research attention, peptide-based approaches remain in early discovery phases. The therapeutic rationale centers on reproducing the lifespan-extending effects of sirtuin overexpression observed in lower organisms..

Sirtuin-Activating Peptides is in the research phase with limited clinical data in humans. Current evidence is primarily derived from preclinical (animal or in vitro) studies.