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Humanin
Overview
A 24-amino acid mitochondrial-derived peptide encoded within the 16S rRNA region of mitochondrial DNA. Humanin exerts cytoprotective and neuroprotective effects by interacting with IGFBP-3, BAX, and the FPRL-1 receptor.
Mechanism of Action
It inhibits apoptosis through suppression of the intrinsic mitochondrial death pathway and reduces amyloid-beta-induced neurotoxicity.
Research Summary & Key Findings
Discovered in 2001 as a survival factor against Alzheimer's disease-related neuronal death. Studies show protection against oxidative stress, atherosclerosis, and age-related cognitive decline. Circulating humanin levels inversely correlate with age and Alzheimer's disease progression (Hashimoto et al., PNAS, 2001).
Clinical Status
Humanin is in the research phase with limited clinical data in humans. Current evidence is primarily derived from preclinical (animal or in vitro) studies.
Administration Routes
References
Primary literature
- PubMed: "Humanin"
Peer-reviewed literature indexed by the National Library of Medicine.
- ClinicalTrials.gov: "Humanin"
Registered interventional and observational studies, including status and phase.
- PubChem: "Humanin"
Chemical structure, molecular properties, and bioactivity data.
Study-level citations for this compound are being verified against the primary sources before publication. The database queries above return the current indexed literature in the meantime.
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View detailsNo lawful pathway today
Humanin is not FDA-approved and does not currently have a lawful prescription or compounding pathway in the United States, so there is nothing for us to sell you here and no consultation to book. That can change: eight peptides moved back to a lawful pathway in February 2026.
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One email, only if this compound's regulatory standing actually moves. Not a newsletter, not a sales sequence.
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List Your PracticeDisclaimer: This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide therapy. The Peptide Association does not endorse or recommend any specific treatment protocol. See our editorial policy for how this content is produced and reviewed.