Sinapultide (KL4 Surfactant)
Overview
Sinapultide is a synthetic 21-amino acid peptide that mimics the structure and function of surfactant protein B, a critical component of pulmonary surfactant. When combined with phospholipids, sinapultide forms a surface-active complex that reduces alveolar surface tension, improving gas exchange and lung compliance.
Mechanism of Action
It has been investigated primarily for treatment of acute respiratory distress syndrome and neonatal respiratory distress..
Research Summary & Key Findings
Phase II trials in acute lung injury and ARDS populations demonstrated trends toward improved oxygenation but did not meet primary efficacy endpoints for mortality reduction in larger phase III studies. Development was discontinued by the sponsor after results from multicenter trials failed to show significant clinical benefit.
Clinical Status
Sinapultide (KL4 Surfactant) is in the investigational stage. While preclinical and early-phase data exist, it has not received regulatory approval for clinical use in the United States.
Administration Routes
Related Peptides in Recovery
BPC-157
Research PhaseA synthetic gastric pentadecapeptide derived from a protein found in human gastric juice. BPC-157 promotes angiogenesis ...
View detailsTB-500 (Thymosin Beta-4)
In Clinical TrialsThymosin Beta-4 is a 43-amino acid actin-sequestering protein involved in cell migration, differentiation, and tissue re...
View detailsGHK-Cu
Research PhaseA naturally occurring copper-binding tripeptide (glycyl-L-histidyl-L-lysine) found in human plasma, saliva, and urine. G...
View detailsDSIP (Delta Sleep-Inducing Peptide)
Research PhaseA naturally occurring nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) originally isolated from cerebral venous blood o...
View detailsFind a Provider
Find a verified provider who offers Sinapultide (KL4 Surfactant) therapy in your area.
Browse Provider MapFind a Pharmacy
Browse PCAB-accredited and FDA 503B-registered compounding pharmacies that supply Sinapultide (KL4 Surfactant).
Pharmacy DirectoryJoin the Association
Access exclusive peptide protocols, provider resources, and community support.
List Your PracticeDisclaimer: This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide therapy. The Peptide Association does not endorse or recommend any specific treatment protocol.