CognitiveInvestigational

Selank

Intranasal

Overview

A synthetic analog of the endogenous tetrapeptide tuftsin (Thr-Lys-Pro-Arg) with an added Pro-Gly-Pro sequence for stability. Selank exhibits anxiolytic activity comparable to benzodiazepines without sedation, dependence, or withdrawal effects.

Mechanism of Action

It modulates the expression of BDNF, serotonin, dopamine, and norepinephrine, and influences IL-6 and GABA receptor expression..

Research Summary & Key Findings

Approved in Russia for generalized anxiety disorder and as a nootropic. Clinical trials showed anxiolytic effects comparable to medazepam without sedation. Demonstrated immunomodulatory properties through modulation of IL-6 and T-helper cell balance.

Clinical Status

Investigational

Selank is in the investigational stage. While preclinical and early-phase data exist, it has not received regulatory approval for clinical use in the United States.

Administration Routes

Intranasal

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Disclaimer: This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide therapy. The Peptide Association does not endorse or recommend any specific treatment protocol.