HormoneInvestigational

Relamorelin

Subcutaneous injection

Overview

Relamorelin is a synthetic pentapeptide ghrelin receptor agonist designed to stimulate growth hormone secretion and promote gastric motility. It binds selectively to the growth hormone secretagogue receptor type 1a (GHS-R1a), mimicking the action of endogenous ghrelin.

Mechanism of Action

The peptide was developed primarily for the treatment of diabetic gastroparesis and other disorders of gastric emptying, with potential applications in cachexia and functional dyspepsia..

Research Summary & Key Findings

Phase 2 trials in diabetic gastroparesis demonstrated improvements in gastric emptying and symptom reduction, with data presented at Digestive Disease Week in 2017. Despite initial promise, development was discontinued by the sponsor in 2020. Clinical evidence supports prokinetic activity, though no regulatory approval has been obtained.

Clinical Status

Investigational

Relamorelin is in the investigational stage. While preclinical and early-phase data exist, it has not received regulatory approval for clinical use in the United States.

Administration Routes

Subcutaneous injection

Related Peptides in Hormone

CJC-1295

In Clinical Trials

A synthetic analog of growth hormone-releasing hormone (GHRH) with a Drug Affinity Complex (DAC) that binds to albumin, ...

View details

Ipamorelin

In Clinical Trials

A highly selective growth hormone secretagogue that acts on ghrelin/GHS receptors in the pituitary gland to stimulate GH...

View details

Sermorelin

FDA Approved

A synthetic 29-amino acid analog of GHRH representing the shortest fully functional fragment of the native 44-amino acid...

View details

Tesamorelin (Egrifta)

FDA Approved

A synthetic GHRH analog consisting of the 44-amino acid sequence of human GHRH with a trans-3-hexenoic acid modification...

View details

Find a Provider

Find a verified provider who offers Relamorelin therapy in your area.

Browse Provider Map

Find a Pharmacy

Browse PCAB-accredited and FDA 503B-registered compounding pharmacies that supply Relamorelin.

Pharmacy Directory

Join the Association

Access exclusive peptide protocols, provider resources, and community support.

List Your Practice

Disclaimer: This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide therapy. The Peptide Association does not endorse or recommend any specific treatment protocol.