HormoneFDA Approved

PT-141 (Bremelanotide / Vyleesi)

Subcutaneous injection (as needed)

Overview

A synthetic cyclic heptapeptide melanocortin receptor agonist that activates MC3R and MC4R in the central nervous system. Unlike PDE5 inhibitors that act peripherally on vascular smooth muscle, PT-141 works centrally through hypothalamic melanocortin pathways that modulate sexual arousal and desire.

Mechanism of Action

It is a metabolite of Melanotan II without significant melanogenic activity..

Research Summary & Key Findings

FDA-approved in 2019 (Vyleesi) for hypoactive sexual desire disorder (HSDD) in premenopausal women. RECONNECT trials showed statistically significant increases in sexual desire and reduction in distress. First centrally-acting treatment for female sexual dysfunction.

Clinical Status

FDA Approved

PT-141 (Bremelanotide / Vyleesi) has received FDA approval and is available for clinical use under appropriate medical supervision. Consult a qualified healthcare provider for prescribing information.

Administration Routes

Subcutaneous injection (as needed)

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Disclaimer: This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide therapy. The Peptide Association does not endorse or recommend any specific treatment protocol.