HormoneFDA Approved

Pegvisomant (Somavert)

Subcutaneous injection

Overview

Pegvisomant is a PEGylated growth hormone receptor antagonist engineered from human growth hormone with nine amino acid substitutions that confer antagonist properties. The molecule binds to growth hormone receptors but does not activate downstream signaling, effectively blocking the action of endogenous growth hormone.

Mechanism of Action

It is used exclusively for the treatment of acromegaly in patients with inadequate response to surgery or other medical therapies..

Research Summary & Key Findings

FDA approval was granted in 2003 based on pivotal trials demonstrating normalization of IGF-1 levels in the majority of acromegaly patients, with results published in the Journal of Clinical Endocrinology and Metabolism in 2000. Long-term extension studies have confirmed sustained biochemical control and symptom improvement. Pegvisomant is recommended in clinical guidelines for refractory acromegaly.

Clinical Status

FDA Approved

Pegvisomant (Somavert) has received FDA approval and is available for clinical use under appropriate medical supervision. Consult a qualified healthcare provider for prescribing information.

Administration Routes

Subcutaneous injection

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Disclaimer: This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide therapy. The Peptide Association does not endorse or recommend any specific treatment protocol.