Omiganan
Overview
Omiganan is a synthetic 12-amino acid cationic antimicrobial peptide derived from indolicidin, a naturally occurring peptide from bovine neutrophils. It acts by disrupting microbial membranes and demonstrates activity against bacteria, fungi, and some viruses.
Mechanism of Action
Omiganan was developed as a topical agent to prevent catheter-related bloodstream infections through its broad-spectrum antimicrobial properties. Its small size and potent activity made it a candidate for preventing biofilm formation on medical devices..
Research Summary & Key Findings
Phase III trials evaluated omiganan as a catheter site antiseptic gel but did not demonstrate statistically significant reduction in catheter-related bloodstream infections compared to standard care. The FDA issued a Complete Response Letter in 2007 citing insufficient efficacy data. Subsequent development has focused on rosacea and other dermatologic indications, with Phase II trials conducted in acne vulgaris.
Clinical Status
Omiganan is currently undergoing clinical trials. It is not yet FDA-approved and is available only through clinical research settings or investigational protocols.
Administration Routes
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