AntimicrobialFDA Approved

Enfuvirtide (Fuzeon)

Subcutaneous injection (twice daily)

Overview

A 36-amino acid synthetic peptide that inhibits HIV-1 entry into CD4+ T-cells by blocking the gp41-mediated membrane fusion step. Enfuvirtide binds to the first heptad repeat (HR1) region of gp41, preventing the conformational change required for viral-cell membrane fusion.

Mechanism of Action

It is the first and only FDA-approved fusion inhibitor and is active against HIV-1 strains resistant to other antiretroviral drug classes..

Research Summary & Key Findings

FDA-approved in 2003 for treatment-experienced HIV-1 patients. TORO trials demonstrated approximately 1 log10 greater viral load reduction when added to optimized background regimen vs. background alone. Limited by twice-daily subcutaneous injections and frequent injection site reactions. Reserved for heavily treatment-experienced patients due to convenience limitations.

Clinical Status

FDA Approved

Enfuvirtide (Fuzeon) has received FDA approval and is available for clinical use under appropriate medical supervision. Consult a qualified healthcare provider for prescribing information.

Administration Routes

Subcutaneous injection (twice daily)

Related Peptides in Antimicrobial

Magainin 2

Research Phase

Magainin 2 is a 23-amino acid antimicrobial peptide originally isolated from the skin of the African clawed frog Xenopus...

View details

Pexiganan (MSI-78)

In Clinical Trials

Pexiganan is a 22-amino acid synthetic analog of magainin 2 designed to enhance antimicrobial potency and proteolytic st...

View details

Omiganan

In Clinical Trials

Omiganan is a synthetic 12-amino acid cationic antimicrobial peptide derived from indolicidin, a naturally occurring pep...

View details

Iseganan (IB-367)

Investigational

Iseganan is a 17-amino acid synthetic analog of protegrin, a naturally occurring antimicrobial peptide found in porcine ...

View details

Find a Provider

Find a verified provider who offers Enfuvirtide (Fuzeon) therapy in your area.

Browse Provider Map

Find a Pharmacy

Browse PCAB-accredited and FDA 503B-registered compounding pharmacies that supply Enfuvirtide (Fuzeon).

Pharmacy Directory

Join the Association

Access exclusive peptide protocols, provider resources, and community support.

List Your Practice

Disclaimer: This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide therapy. The Peptide Association does not endorse or recommend any specific treatment protocol.