HormoneResearch Phase

Obestatin

Subcutaneous injection, Intravenous

Overview

Obestatin is a 23-amino acid peptide hormone derived from post-translational processing of the ghrelin gene product preproghrelin. It was initially proposed to oppose ghrelin's orexigenic effects by binding to the GPR39 receptor and promoting satiety, though this mechanism remains controversial.

Mechanism of Action

The peptide has been investigated for potential roles in regulating food intake, gastrointestinal motility, and metabolic homeostasis..

Research Summary & Key Findings

Initial reports in 2005 suggested anorectic activity in rodents, but subsequent replication studies yielded inconsistent results and questioned the GPR39 binding hypothesis. Multiple independent laboratories have failed to confirm the original satiety effects, and the physiological role of obestatin remains unclear. Current evidence does not support a clinically meaningful role in appetite regulation.

Clinical Status

Research Phase

Obestatin is in the research phase with limited clinical data in humans. Current evidence is primarily derived from preclinical (animal or in vitro) studies.

Administration Routes

Subcutaneous injectionIntravenous

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Disclaimer: This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide therapy. The Peptide Association does not endorse or recommend any specific treatment protocol.