HormoneFDA Approved

Mecasermin (Increlex)

Subcutaneous injection

Overview

Mecasermin is recombinant human insulin-like growth factor 1 (IGF-1) consisting of 70 amino acids identical to the endogenous peptide hormone. It binds to IGF-1 receptors to promote growth and anabolic processes, bypassing the need for growth hormone receptor signaling.

Mechanism of Action

Mecasermin is indicated specifically for children with severe primary IGF-1 deficiency or growth hormone gene deletion who have developed neutralizing antibodies to growth hormone..

Research Summary & Key Findings

FDA approval was granted in 2005 for primary IGF-1 deficiency based on clinical trials showing improved linear growth in children who cannot respond to growth hormone therapy. Post-marketing data have refined use to the narrowest indicated population due to safety concerns including hypoglycemia and tonsillar hypertrophy. Mecasermin remains the only approved therapy for severe primary IGF-1 deficiency.

Clinical Status

FDA Approved

Mecasermin (Increlex) has received FDA approval and is available for clinical use under appropriate medical supervision. Consult a qualified healthcare provider for prescribing information.

Administration Routes

Subcutaneous injection

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Disclaimer: This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide therapy. The Peptide Association does not endorse or recommend any specific treatment protocol.