Klotho Peptide

Klotho is a transmembrane protein of approximately 1012 amino acids that exists in membrane-bound and secreted forms, with the soluble ectodomain functioning as a circulating factor. Klotho acts as a coreceptor for fibroblast growth factor 23 in phosphate metabolism and independently influences insulin signaling, oxidative stress, and cellular senescence pathways.

Reduced klotho expression is associated with accelerated aging phenotypes in mice, while overexpression extends lifespan in rodent models. Therapeutic development focuses on peptide fragments or recombinant forms to replicate klotho's protective effects in age-related conditions..

Klotho Peptide is in the research phase with limited clinical data in humans. Current evidence is primarily derived from preclinical (animal or in vitro) studies.