HormoneIn Clinical Trials

Kisspeptin

Intravenous, Subcutaneous injection

Overview

A neuropeptide encoded by the KISS1 gene that serves as the master upstream regulator of the hypothalamic-pituitary-gonadal (HPG) axis. Kisspeptin activates GPR54 (KISS1R) on GnRH neurons, stimulating gonadotropin-releasing hormone secretion and subsequent LH and FSH release.

Mechanism of Action

It plays a critical role in puberty onset, reproductive function, and fertility regulation..

Research Summary & Key Findings

Identified as essential for puberty initiation and reproductive function (loss-of-function mutations cause hypogonadotropic hypogonadism). Clinical studies show potential for controlled ovarian stimulation in IVF with lower OHSS risk. Kisspeptin-54 administration triggers predictable LH surges for egg maturation (Dhillo et al., J Clin Invest, 2012).

Clinical Status

In Clinical Trials

Kisspeptin is currently undergoing clinical trials. It is not yet FDA-approved and is available only through clinical research settings or investigational protocols.

Administration Routes

IntravenousSubcutaneous injection

Related Peptides in Hormone

CJC-1295

In Clinical Trials

A synthetic analog of growth hormone-releasing hormone (GHRH) with a Drug Affinity Complex (DAC) that binds to albumin, ...

View details

Ipamorelin

In Clinical Trials

A highly selective growth hormone secretagogue that acts on ghrelin/GHS receptors in the pituitary gland to stimulate GH...

View details

Sermorelin

FDA Approved

A synthetic 29-amino acid analog of GHRH representing the shortest fully functional fragment of the native 44-amino acid...

View details

Tesamorelin (Egrifta)

FDA Approved

A synthetic GHRH analog consisting of the 44-amino acid sequence of human GHRH with a trans-3-hexenoic acid modification...

View details

Find a Provider

Find a verified provider who offers Kisspeptin therapy in your area.

Browse Provider Map

Find a Pharmacy

Browse PCAB-accredited and FDA 503B-registered compounding pharmacies that supply Kisspeptin.

Pharmacy Directory

Join the Association

Access exclusive peptide protocols, provider resources, and community support.

List Your Practice

Disclaimer: This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide therapy. The Peptide Association does not endorse or recommend any specific treatment protocol.