HormoneResearch Phase

Ghrelin (Native)

Intravenous

Overview

Ghrelin is a naturally occurring 28-amino acid peptide hormone produced primarily in the stomach with an essential octanoyl modification at serine-3 required for biological activity. It functions as the endogenous ligand for the growth hormone secretagogue receptor (GHS-R1a), stimulating growth hormone release, appetite, and gastric motility.

Mechanism of Action

Ghrelin plays a central role in energy homeostasis, feeding behavior, and metabolic regulation..

Research Summary & Key Findings

Native ghrelin has been studied in clinical research settings for cachexia, gastroparesis, and anorexia, with small trials demonstrating increased food intake and gastric emptying. Rapid enzymatic degradation and short half-life limit therapeutic utility, leading to development of synthetic analogues with improved stability. No formulation of native ghrelin has achieved regulatory approval for clinical use.

Clinical Status

Research Phase

Ghrelin (Native) is in the research phase with limited clinical data in humans. Current evidence is primarily derived from preclinical (animal or in vitro) studies.

Administration Routes

Intravenous

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Disclaimer: This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide therapy. The Peptide Association does not endorse or recommend any specific treatment protocol.