FGL Peptide
Overview
FGL peptide is a 15-amino acid synthetic sequence derived from the neural cell adhesion molecule (NCAM) that mimics the fibronectin-like domain. It promotes neurite outgrowth and synaptic plasticity by engaging NCAM and fibroblast growth factor receptors without requiring direct cell-cell adhesion.
Mechanism of Action
The peptide has been investigated for neuroprotective and cognitive-enhancing properties in models of neurological injury and disease..
Research Summary & Key Findings
Preclinical rodent studies have demonstrated improved spatial learning and memory in models of aging and neurodegeneration. Research published in the Journal of Neuroscience and related journals has shown FGL enhances hippocampal long-term potentiation and protects against excitotoxic injury. Human clinical trials have not been reported in peer-reviewed literature.
Clinical Status
FGL Peptide is in the research phase with limited clinical data in humans. Current evidence is primarily derived from preclinical (animal or in vitro) studies.
Administration Routes
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