HormoneFDA Approved

Cosyntropin (Cortrosyn)

Intravenous, Intramuscular injection

Overview

A synthetic peptide consisting of the first 24 amino acids of the 39-amino acid adrenocorticotropic hormone (ACTH). Cosyntropin retains full biological activity of native ACTH for stimulating adrenal cortisol production and is used as a diagnostic agent in the ACTH stimulation test to evaluate adrenal gland function.

Mechanism of Action

It binds to the MC2R receptor on adrenocortical cells, activating steroidogenesis..

Research Summary & Key Findings

FDA-approved as a diagnostic agent for adrenal insufficiency. The standard-dose (250 mcg) and low-dose (1 mcg) ACTH stimulation tests are cornerstones of adrenal function assessment. A cortisol response below 18-20 mcg/dL at 30-60 minutes post-injection indicates adrenal insufficiency. Widely used in endocrinology with an excellent safety profile.

Clinical Status

FDA Approved

Cosyntropin (Cortrosyn) has received FDA approval and is available for clinical use under appropriate medical supervision. Consult a qualified healthcare provider for prescribing information.

Administration Routes

IntravenousIntramuscular injection

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Disclaimer: This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide therapy. The Peptide Association does not endorse or recommend any specific treatment protocol.