HormoneFDA Approved

Capromorelin (Entyce)

Oral

Overview

Capromorelin is a selective ghrelin receptor agonist, or growth hormone secretagogue, that mimics the endogenous peptide hormone ghrelin by binding to the GHS-R1a receptor in the hypothalamus and pituitary. Activation of ghrelin receptors stimulates appetite, promotes growth hormone release, and modulates energy balance, providing a therapeutic rationale for conditions characterized by inappetence and weight loss.

Mechanism of Action

The compound is formulated as an oral solution, distinguishing it from injectable peptide therapies..

Research Summary & Key Findings

Capromorelin received FDA approval in 2018 for the management of weight loss in dogs under the trade name Entyce, based on veterinary clinical trials demonstrating increased food consumption and weight gain. No human clinical development program has been publicly disclosed, and the compound remains exclusively approved for veterinary use in the United States.

Clinical Status

FDA Approved

Capromorelin (Entyce) has received FDA approval and is available for clinical use under appropriate medical supervision. Consult a qualified healthcare provider for prescribing information.

Administration Routes

Oral

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Disclaimer: This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide therapy. The Peptide Association does not endorse or recommend any specific treatment protocol.