BoneFDA Approved

BMP-7 (Osteogenic Protein-1)

Surgical implantation

Overview

BMP-7, also known as osteogenic protein-1 (OP-1), is a member of the bone morphogenetic protein family with a mature homodimeric structure of approximately 139 amino acids per monomer. Like other BMPs, it signals through serine/threonine kinase receptors to activate SMAD transcription factors, promoting differentiation of mesenchymal cells into osteoblasts and chondrocytes.

Mechanism of Action

The recombinant form is delivered on a bovine collagen matrix to provide localized, sustained release. BMP-7 also exhibits renoprotective effects in preclinical models, though clinical development in nephrology has not advanced..

Research Summary & Key Findings

Recombinant human BMP-7 (OP-1 Putty) received FDA approval under a Humanitarian Device Exemption in 2001 for revision posterolateral lumbar spinal fusion and recalcitrant long bone nonunions where autograft is not feasible. Clinical trials demonstrated comparable efficacy to autograft in promoting bone healing in nonunion fractures. The product was voluntarily withdrawn from the U.S. market in 2014 by the manufacturer due to commercial considerations, though it remains available in select international markets.

Clinical Status

FDA Approved

BMP-7 (Osteogenic Protein-1) has received FDA approval and is available for clinical use under appropriate medical supervision. Consult a qualified healthcare provider for prescribing information.

Administration Routes

Surgical implantation

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Disclaimer: This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide therapy. The Peptide Association does not endorse or recommend any specific treatment protocol.