BoneFDA Approved

Teriparatide (Forteo)

Subcutaneous injection (daily)

Overview

A recombinant form of the first 34 amino acids of human parathyroid hormone (PTH 1-34). When administered intermittently via daily subcutaneous injection, teriparatide stimulates osteoblastic bone formation more than osteoclastic resorption, producing a net anabolic effect on bone.

Mechanism of Action

It activates the PTH1 receptor on osteoblasts, increasing Wnt signaling, osteoblast differentiation, and survival while reducing sclerostin expression..

Research Summary & Key Findings

FDA-approved in 2002 for osteoporosis in postmenopausal women and men at high fracture risk. Fracture Prevention Trial showed 65% reduction in vertebral fractures and 53% reduction in nonvertebral fractures (Neer et al., NEJM, 2001). Treatment limited to 2 years due to theoretical osteosarcoma risk observed in rats at high doses, though no human cases have been attributed to teriparatide use.

Clinical Status

FDA Approved

Teriparatide (Forteo) has received FDA approval and is available for clinical use under appropriate medical supervision. Consult a qualified healthcare provider for prescribing information.

Administration Routes

Subcutaneous injection (daily)

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PTH (1-34) Analogs

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Disclaimer: This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide therapy. The Peptide Association does not endorse or recommend any specific treatment protocol.