ACE-031 (Ramatercept)
Overview
ACE-031 is a recombinant fusion protein combining the extracellular domain of the activin receptor type IIB with a human IgG1 Fc domain. This soluble receptor acts as a decoy to bind and neutralize myostatin, activin, and other negative regulators of muscle growth.
Mechanism of Action
By inhibiting these TGF-beta superfamily ligands, ACE-031 was designed to promote muscle hypertrophy in conditions characterized by muscle wasting..
Research Summary & Key Findings
Phase 2 clinical trials in postmenopausal women and healthy volunteers demonstrated dose-dependent increases in muscle mass and decreases in fat mass. Development was voluntarily suspended in 2013 following observations of adverse effects on skin vasculature, including telangiectasias and epistaxis. No subsequent clinical trials have been registered or published.
Clinical Status
ACE-031 (Ramatercept) is in the investigational stage. While preclinical and early-phase data exist, it has not received regulatory approval for clinical use in the United States.
Administration Routes
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