IGF-1 DES (1-3)
Overview
IGF-1 DES (1-3) is a truncated analogue of insulin-like growth factor 1 lacking the first three N-terminal amino acids (glycine-proline-glutamate). This structural modification prevents binding to IGF binding proteins in serum, resulting in a shorter half-life but significantly increased potency at the IGF-1 receptor compared to native IGF-1.
Mechanism of Action
The peptide is hypothesized to promote localized muscle hypertrophy and tissue repair through enhanced receptor activation in target tissues..
Research Summary & Key Findings
No controlled clinical trials have been published in peer-reviewed journals. Evidence is limited to preclinical cell culture and animal models demonstrating increased myoblast proliferation and differentiation. This agent remains unregulated and its safety and efficacy in humans have not been established through formal investigation.
Clinical Status
IGF-1 DES (1-3) is in the research phase with limited clinical data in humans. Current evidence is primarily derived from preclinical (animal or in vitro) studies.
Administration Routes
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