Sinapultide (KL4 Surfactant)
Overview
Sinapultide is a synthetic 21-amino acid peptide that mimics the structure and function of surfactant protein B, a critical component of pulmonary surfactant. When combined with phospholipids, sinapultide forms a surface-active complex that reduces alveolar surface tension, improving gas exchange and lung compliance. It has been investigated primarily for treatment of acute respiratory distress syndrome and neonatal respiratory distress.
Key Research Findings
Phase II trials in acute lung injury and ARDS populations demonstrated trends toward improved oxygenation but did not meet primary efficacy endpoints for mortality reduction in larger phase III studies. Development was discontinued by the sponsor after results from multicenter trials failed to show significant clinical benefit.
Intratracheal instillation
Investigational
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