Granulysin
Overview
Granulysin is a 15-kDa antimicrobial and cytolytic protein expressed by cytotoxic T lymphocytes and natural killer cells. It disrupts microbial and tumor cell membranes via lipid interactions and induces apoptosis. The therapeutic rationale includes treatment of intracellular infections and cancer immunotherapy.
Key Research Findings
Preclinical studies have shown granulysin-mediated killing of mycobacteria, including Mycobacterium tuberculosis, as well as antitumor activity in vitro and in animal models. No clinical trials or approved formulations are currently available, and development remains at the research stage.
Intravenous, Subcutaneous injection
Research Phase
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