Dalargin
Overview
Dalargin is a synthetic hexapeptide analog of leucine-enkephalin with enhanced metabolic stability due to D-amino acid substitutions. It acts as a selective delta opioid receptor agonist with peripheral and central effects, including modulation of stress responses, anti-inflammatory activity, and cytoprotection in gastrointestinal and vascular tissues. Unlike classical opioids, dalargin exhibits reduced central analgesic potency but pronounced tissue-protective properties.
Key Research Findings
Dalargin has been used clinically in Russia and some Eastern European countries for treatment of gastric ulcers, pancreatitis, and stress-related mucosal injury since the 1980s. Peer-reviewed evidence in Western literature is limited, with most data derived from Soviet-era clinical studies and pharmacological characterization in animal models.
Intravenous, Intramuscular injection
Investigational
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