Beta-Defensin 3
Overview
Beta-defensin 3 (hBD-3) is an antimicrobial peptide of approximately 45 amino acids with potent activity against a wide range of pathogens, including antibiotic-resistant strains. It acts by permeabilizing microbial membranes and modulating host immune responses. Therapeutic applications include topical antimicrobial therapy and vaccine adjuvants.
Key Research Findings
In vitro and animal studies have demonstrated hBD-3 efficacy against methicillin-resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosa, and Candida species. Translation to clinical use has been limited by challenges in large-scale synthesis and formulation stability, with no approved products to date.
Topical, Subcutaneous injection
Research Phase
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