ARA-290
Overview
A synthetic 11-amino acid peptide derived from the structure of erythropoietin (EPO) that selectively activates the innate repair receptor (IRR), a heteromer of the EPO receptor and the beta common receptor (CD131). Unlike EPO, ARA-290 does not stimulate erythropoiesis or promote thrombosis. It produces cytoprotective, anti-inflammatory, and tissue-reparative effects by activating the IRR on neurons, immune cells, and endothelial cells.
Key Research Findings
Phase 2 trials in patients with sarcoidosis-related small fiber neuropathy showed significant improvement in corneal nerve fiber density and reduction in neuropathic pain (Dahan et al., Mol Med, 2013). Preclinical studies demonstrated neuroprotective effects in diabetic neuropathy and cardiac ischemia-reperfusion injury. The selective IRR activation without erythropoietic effects avoids the thrombotic risks that limited EPO-based neuroprotection strategies.
Subcutaneous injection, Intravenous
In Clinical Trials
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