Alpha-MSH
Overview
Alpha-melanocyte-stimulating hormone (alpha-MSH) is a 13-amino-acid peptide derived from proopiomelanocortin (POMC). It acts via melanocortin receptors to exert potent anti-inflammatory and immunomodulatory effects, including suppression of proinflammatory cytokines and inhibition of nuclear factor kappa B (NF-kB). Therapeutic interest spans inflammatory and autoimmune disorders.
Key Research Findings
Preclinical models have demonstrated efficacy in reducing inflammation in conditions such as colitis, arthritis, and uveitis. Clinical translation has been limited, with synthetic analogs under exploration, but no large-scale trials or approvals for alpha-MSH itself have been reported.
Subcutaneous injection, Intravenous
Research Phase
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