RenalFDA Approved

Vasopressin (ADH)

Intravenous, Intramuscular injection, Subcutaneous injection

Overview

A nine-amino acid cyclic peptide hormone (arginine vasopressin) produced in the hypothalamus and released from the posterior pituitary. Vasopressin acts on V1a receptors (vascular smooth muscle vasoconstriction), V1b receptors (ACTH release from pituitary), and V2 receptors (aquaporin-2 insertion in renal collecting ducts for water reabsorption).

Mechanism of Action

It is essential for body water homeostasis and hemodynamic stability..

Research Summary & Key Findings

FDA-approved for diabetes insipidus, prevention and treatment of postoperative abdominal distention, and as a vasopressor in vasodilatory shock. VASST trial evaluated vasopressin vs. norepinephrine in septic shock with inconclusive primary outcome but benefit in less severe sepsis subgroup (Russell et al., NEJM, 2008). Recommended in ACLS guidelines as an alternative to epinephrine in cardiac arrest.

Clinical Status

FDA Approved

Vasopressin (ADH) has received FDA approval and is available for clinical use under appropriate medical supervision. Consult a qualified healthcare provider for prescribing information.

Administration Routes

IntravenousIntramuscular injectionSubcutaneous injection

Related Peptides in Renal

Desmopressin (DDAVP)

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A synthetic analog of vasopressin with enhanced V2 receptor selectivity and minimal V1a vasopressor activity. Desmopress...

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Terlipressin

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A synthetic vasopressin analog and prodrug that is cleaved by endopeptidases to release lysine-vasopressin. Terlipressin...

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Disclaimer: This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide therapy. The Peptide Association does not endorse or recommend any specific treatment protocol.